| Company Name: |
Zhejiang Huida Biotech Co., LTD
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| Tel: |
0571-89903022 18679456698 |
| Email: |
zilong@hizyme.com |
| Products Intro: |
Product Name:4-(2-Hydroxyacetyl)-8-hydroxyisocoumarin
CAS:146-04-3
Purity:99% HPLC Package:10mg；100mg；1g；10g；100g
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Oosponol manufacturers
- Oosponol
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- $2800.00
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2026-05-11
- CAS:146-04-3
- Purity:
- Supply Ability: 10g
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| | Oosponol Basic information |
| Product Name: | Oosponol | | Synonyms: | Oosponol;4-(1-Oxo-2-hydroxyethyl)-8-hydroxyisocoumarin;4-Glycolyl-8-hydroxyisocoumarin;8-Hydroxy-4-(hydroxyacetyl)-1H-2-benzopyran-1-one;Lenzitin;Brn 1287762;Isocoumarin, 4-glycolyl-8-hydroxy- | | CAS: | 146-04-3 | | MF: | C11H8O5 | | MW: | 220.18 | | EINECS: | | | Product Categories: | | | Mol File: | 146-04-3.mol |  |
| | Oosponol Chemical Properties |
| Melting point | 170 °C | | Boiling point | 485.930±45.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.548±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 6.704±0.20(predicted) | | LogP | 0.789 (est) |
| Toxicity | LD50 oral in rat: 250mg/kg |
| | Oosponol Usage And Synthesis |
| Uses | Oosponol is a dopamine beta-hydroxylase inhibitor exhibiting hypotensive effects.Oospongol has strong antifungal activity against many antagonistic fungi[1][2]. | | in vivo | Oosponol (6.25 mg/kg, 3.1 mg/kg, ip, Once) can lower blood pressure in spontaneously hypertensive rats model[1]. | Animal Model: | Spontaneously hypertensive rats[1] | | Dosage: | 6.25 mg/kg, 3.1 mg/kg | | Administration: | Intraperitoneal injection, once. | | Result: | The intraperitoneal injection of 6.25 mg/kg lowered the pressure from 186 mm to 138~112 mm, the intraperitoneal injection of 3.1 mg/kg lowered the pressure from 185 mm to 164~131 mm[1]. |
| Animal Model: | Spontaneously hypertensive rats[1] | | Dosage: | 6.25 mg/kg, 3.1 mg/kg | | Administration: | Intraperitoneal injection, once. | | Result: | The intraperitoneal injection of 6.25 mg/kg lowered the pressure from 186 mm to 138~112 mm, the intraperitoneal injection of 3.1 mg/kg lowered the pressure from 185 mm to 164~131 mm. |
| | References | [1] Umezawa H, et al.. Dopamine -hydroxylase inhibitor produced by Gloeophyllum striatum and its identity with oosponol. J Antibiot (Tokyo). 1972 Apr;25(4):239-42. DOI:10.7164/antibiotics.25.239
[2] Sonnenbichler J,et al. Influence of the Gloeophyllum metabolite oosponol and some synthetic analogues on protein and RNA synthesis in target cells. Eur J Biochem. 1997 May 15;246(1):45-9. DOI:10.1111/j.1432-1033.1997.t01-2-00045.x |
| | Oosponol Preparation Products And Raw materials |
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