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DPPE FUMARATE manufacturers
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| | DPPE FUMARATE Basic information |
| Product Name: | DPPE FUMARATE | | Synonyms: | N,N-DIETHYL-2-[4-(PHENYLMETHYL)PHENOXY]ETHANAMINE FUMARATE;DPPE FUMARATE;Tesmilifene fumarate;inhibit,anti-histaminic,Tesmilifene fumarate,DPPE,Histamine Receptor,seizure,Tesmilifene,chemotherapy,Inhibitor;2-(4-Benzylphenoxy)-N,N-diethylethanamine 2-butenedioate(1:1);DPPE fumarate Tesmilifene;Tesmilifene fumarate, 10 mM in DMSO | | CAS: | 1185241-83-1 | | MF: | C30H28O4P2 | | MW: | 514.49 | | EINECS: | | | Product Categories: | Histamine receptor | | Mol File: | Mol File |  |
| | DPPE FUMARATE Chemical Properties |
| storage temp. | Desiccate at -20°C | | solubility | Soluble to 100 mM in sterile water | | form | Powder | | color | White to off-white |
| | DPPE FUMARATE Usage And Synthesis |
| Uses | Tesmilifene fumarate (DPPE fumarate), an H1C receptor antagonist, potentiates a wide range of cytotoxics and even to offer some protection of normal cells[1][2]. | | Biological Activity | Binds with high affinity to the antiestrogen binding site but not to the estrogen receptor. An inhibitor of histamine binding at the intracellular histamine (H lc ) site. | | in vivo | Tesmilifene (DPPE, 20 mg/kg (s.c.) and 20 μg (icv in 5 μL)) potentiated seizures induced by both convulsants[2]. | Animal Model: | Male BKTO mice (25-45 g)[2]. | | Dosage: | 20 mg/kg (s.c.) and 20 μg (icv in 5 μL). | | Administration: | S.C. and icv. | | Result: | Potentiated seizures induced by both convulsants. |
| | References | [1] Mark Vincent, et al. Tesmilifene may enhance breast cancer chemotherapy by killing a clone of aggressive, multi-drug resistant cells through its action on the p-glycoprotein pump. Med Hypotheses. 2006;66(4):715-31. DOI:10.1016/j.mehy.2005.11.005
[2] G Sturman, et al. Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice Agents Actions. 1994 Jun;41 Spec No:C68-9. DOI:10.1007/BF02007771 |
| | DPPE FUMARATE Preparation Products And Raw materials |
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