8H-Purin-8-one, 2-amino-9-(3-deoxy-β-D-erythro-pentofuranosyl)-7,9-dihydro-7-(2-propyn-1-yl)-

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8H-Purin-8-one, 2-amino-9-(3-deoxy-β-D-erythro-pentofuranosyl)-7,9-dihydro-7-(2-propyn-1-yl)- Suppliers list
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8H-Purin-8-one, 2-amino-9-(3-deoxy-β-D-erythro-pentofuranosyl)-7,9-dihydro-7-(2-propyn-1-yl)- manufacturers
8H-Purin-8-one, 2-amino-9-(3-deoxy-β-D-erythro-pentofuranosyl)-7,9-dihydro-7-(2-propyn-1-yl)- Basic information
Product Name:8H-Purin-8-one, 2-amino-9-(3-deoxy-β-D-erythro-pentofuranosyl)-7,9-dihydro-7-(2-propyn-1-yl)-
Synonyms:2-Amino-7-propargyl-7,8-dihydro-8-oxo-9-(beta-D-3-deoxy-ribofuranosyl)purine;8H-Purin-8-one, 2-amino-9-(3-deoxy-β-D-erythro-pentofuranosyl)-7,9-dihydro-7-(2-propyn-1-yl)-
CAS:2389988-75-2
MF:C13H15N5O4
MW:305.29
EINECS:
Product Categories:
Mol File:2389988-75-2.mol
8H-Purin-8-one, 2-amino-9-(3-deoxy-β-D-erythro-pentofuranosyl)-7,9-dihydro-7-(2-propyn-1-yl)- Structure
8H-Purin-8-one, 2-amino-9-(3-deoxy-β-D-erythro-pentofuranosyl)-7,9-dihydro-7-(2-propyn-1-yl)- Chemical Properties
Boiling point 624.9±65.0 °C(Predicted)
density 1.584±0.06 g/cm3(Predicted)
pka13.85±0.60(Predicted)
Safety Information
MSDS Information
8H-Purin-8-one, 2-amino-9-(3-deoxy-β-D-erythro-pentofuranosyl)-7,9-dihydro-7-(2-propyn-1-yl)- Usage And Synthesis
Uses2-Amino-7-propargyl-7,8-dihydro-8-oxo-9-(beta-D-3-deoxy-ribofuranosyl)purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 2-Amino-7-propargyl-7,8-dihydro-8-oxo-9-(beta-D-3-deoxy-ribofuranosyl)purine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
References[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
8H-Purin-8-one, 2-amino-9-(3-deoxy-β-D-erythro-pentofuranosyl)-7,9-dihydro-7-(2-propyn-1-yl)- Preparation Products And Raw materials
Tag:8H-Purin-8-one, 2-amino-9-(3-deoxy-β-D-erythro-pentofuranosyl)-7,9-dihydro-7-(2-propyn-1-yl)-(2389988-75-2) Related Product Information
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