4,7,10,13,16-Pentaoxaoctadecanamide, N-[3-[[[4-[6-amino-5-(1,2,3,4-tetrahydro-1-oxo-6-isoquinolinyl)-3-pyridinyl]phenyl]sulfonyl]cyclopropylamino]propyl]-18-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-

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4,7,10,13,16-Pentaoxaoctadecanamide, N-[3-[[[4-[6-amino-5-(1,2,3,4-tetrahydro-1-oxo-6-isoquinolinyl)-3-pyridinyl]phenyl]sulfonyl]cyclopropylamino]propyl]-18-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- manufacturers

  • WH-10417-099
  • WH-10417-099 pictures
  • 2026-04-20
  • CAS:2769753-42-4
  • Purity:
  • Supply Ability: 10g
4,7,10,13,16-Pentaoxaoctadecanamide, N-[3-[[[4-[6-amino-5-(1,2,3,4-tetrahydro-1-oxo-6-isoquinolinyl)-3-pyridinyl]phenyl]sulfonyl]cyclopropylamino]propyl]-18-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Basic information
Product Name:4,7,10,13,16-Pentaoxaoctadecanamide, N-[3-[[[4-[6-amino-5-(1,2,3,4-tetrahydro-1-oxo-6-isoquinolinyl)-3-pyridinyl]phenyl]sulfonyl]cyclopropylamino]propyl]-18-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
Synonyms:4,7,10,13,16-Pentaoxaoctadecanamide, N-[3-[[[4-[6-amino-5-(1,2,3,4-tetrahydro-1-oxo-6-isoquinolinyl)-3-pyridinyl]phenyl]sulfonyl]cyclopropylamino]propyl]-18-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-;WH-10417-099;N-[3-[[[4-[6-Amino-5-(1,2,3,4-tetrahydro-1-oxo-6-isoquinolinyl)-3-pyridinyl]phenyl]sulfonyl]cyclopropylamino]propyl]-18-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-4,7,10,13,16-pentaoxaoctadecanamide
CAS:2769753-42-4
MF:C52H62N8O13S
MW:1039.16
EINECS:
Product Categories:
Mol File:2769753-42-4.mol
4,7,10,13,16-Pentaoxaoctadecanamide, N-[3-[[[4-[6-amino-5-(1,2,3,4-tetrahydro-1-oxo-6-isoquinolinyl)-3-pyridinyl]phenyl]sulfonyl]cyclopropylamino]propyl]-18-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Structure
4,7,10,13,16-Pentaoxaoctadecanamide, N-[3-[[[4-[6-amino-5-(1,2,3,4-tetrahydro-1-oxo-6-isoquinolinyl)-3-pyridinyl]phenyl]sulfonyl]cyclopropylamino]propyl]-18-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Chemical Properties
density 1.43±0.1 g/cm3(Predicted)
pka10.74±0.40(Predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
4,7,10,13,16-Pentaoxaoctadecanamide, N-[3-[[[4-[6-amino-5-(1,2,3,4-tetrahydro-1-oxo-6-isoquinolinyl)-3-pyridinyl]phenyl]sulfonyl]cyclopropylamino]propyl]-18-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Usage And Synthesis
UsesWH-10417-099 is a CRBN-type PROTAC multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases). WH-10417-099 induces protein degradation through the ubiquitin biotinylation (E-STUB) pathway and consists of the target protein ligand (red part) PI3Kγ ligand 1 (HY-168319), the E3 ubiquitin ligase ligand (blue part) Thalidomide 4-fluoride (HY-41547) and the PROTAC linker (black part) Amino-PEG5-C2-acid (HY-115384). The E3 ligase ligand and linker can form a conjugate Pomalidomide 4'-PEG5-acid (HY-131647).
IC 50Cereblon
References[1] Donovan KA, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020;183(6):1714-1731.e10. DOI:10.1016/j.cell.2020.10.038
4,7,10,13,16-Pentaoxaoctadecanamide, N-[3-[[[4-[6-amino-5-(1,2,3,4-tetrahydro-1-oxo-6-isoquinolinyl)-3-pyridinyl]phenyl]sulfonyl]cyclopropylamino]propyl]-18-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Preparation Products And Raw materials
Tag:4,7,10,13,16-Pentaoxaoctadecanamide, N-[3-[[[4-[6-amino-5-(1,2,3,4-tetrahydro-1-oxo-6-isoquinolinyl)-3-pyridinyl]phenyl]sulfonyl]cyclopropylamino]propyl]-18-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-(2769753-42-4) Related Product Information
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