(3a,5b,7a,12a)-3,12-dihydroxy-7-(sulfooxy)-Cholan-24-oic acid manufacturers
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| | (3a,5b,7a,12a)-3,12-dihydroxy-7-(sulfooxy)-Cholan-24-oic acid Basic information |
| Product Name: | (3a,5b,7a,12a)-3,12-dihydroxy-7-(sulfooxy)-Cholan-24-oic acid | | Synonyms: | (3a,5b,7a,12a)-3,12-dihydroxy-7-(sulfooxy)-Cholan-24-oic acid;Cholic Acid 7-sulfate (7-SCA);Cholan-24-oic acid, 3,12-dihydroxy-7-(sulfooxy)-, (3α,5β,7α,12α)-;7-Sulfocholic acid;Cholic Acid 7-sulfate | | CAS: | 60320-05-0 | | MF: | C24H40O8S | | MW: | 488.63 | | EINECS: | | | Product Categories: | | | Mol File: | 60320-05-0.mol |  |
| | (3a,5b,7a,12a)-3,12-dihydroxy-7-(sulfooxy)-Cholan-24-oic acid Chemical Properties |
| density | 1.33±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 1 mg/ml; DMSO: 0.3 mg/ml; PBS (pH 7.2): 1 mg/ml | | form | A crystalline solid | | pka | -3.54±0.18(Predicted) | | color | White to off-white |
| | (3a,5b,7a,12a)-3,12-dihydroxy-7-(sulfooxy)-Cholan-24-oic acid Usage And Synthesis |
| Description | Cholic acid 7-sulfate is a metabolite of the primary bile acid cholic acid . It is produced by conjugation of a sulfate group with the hydroxy group at position 7 of cholic acid in the liver and gut. Fecal levels of cholic acid 7-sulfate are increased in male, but not female, mice fed a diet supplemented with cholic acid or chenodeoxycholic acid . | | Uses | Cholic acid 7-sulfate (7-Sulfocholic acid), a metabolite of Cholic acid, is a Takeda G-protein receptor 5 (TGR5) agonist. Cholic acid 7-sulfate can increase Tgr5 expression and induce GLP-1 secretion[1]. | | Definition | ChEBI: 7-Sulfocholic acid is a cholanoid. It is a conjugate acid of a cholate 7-sulfate(2-). | | References | [1] Chaudhari SN, et, al. Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects. Nat Chem Biol. 2021 Jan;17(1):20-29. DOI:10.1038/s41589-020-0604-z |
| | (3a,5b,7a,12a)-3,12-dihydroxy-7-(sulfooxy)-Cholan-24-oic acid Preparation Products And Raw materials |
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