(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one CAS#: 187523-35-9

(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one

生物活性靶点体外研究体内研究用途与合成方法 MSDS (3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one价格(试剂级) 上下游产品信息

中文名称	(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
中文同义词	化合物FLINDOKALNER;MAXIPOST,钾通道调节剂;(S)-3-(5-氯-2-甲氧基苯基)-3-氟-6-(三氟甲基)吲哚啉-2-酮;化合物FLINDOKALNER,10 MM DMSO 溶液
英文名称	(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
英文同义词	(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one;(3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one;BMS-204352 (BMS 204352;2H-Indol-2-one, 3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-, (3S)-;Flindokalner BMS-204352;inhibit,KcsA,Flindokalner,neuronal,ventricular,effects,BMS204352,anxiolytic,subtype,Potassium Channel,Inhibitor,BMS 204352,myocytes,current;(S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)indolin-2-one;Flindokalner, 10 mM in DMSO
CAS号	187523-35-9
分子式	C16H10ClF4NO2
分子量	359.7
EINECS号
相关类别
Mol文件	187523-35-9.mol
结构式

(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one 性质

沸点	436.9±45.0 °C(Predicted)
密度	1.50±0.1 g/cm3(Predicted)
储存条件	Store at -20°C
溶解度	在 DMSO 中溶解度为 100 mM，在乙醇中溶解度为 100 mM
形态	粉末
酸度系数(pKa)	10.43±0.40(Predicted)
颜色	白色至米白色
InChI	InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1
InChIKey	ULYONBAOIMCNEH-HNNXBMFYSA-N
SMILES	N1C2=C(C=CC(C(F)(F)F)=C2)[C@@](C2=CC(Cl)=CC=C2OC)(F)C1=O

(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one 用途与合成方法

生物活性

Flindokalner (BMS-204352) 是钾离子通道 (potassium channel) 调节剂。Flindokalner 是在 HEK293 细胞中表达的所有神经元 Kv7 通道亚型的正调节剂。Flindokalner 是一种大电导钙激活 K 通道 (BKca) 正向调节剂。Flindokalner 在 Kv7.1 通道 (Ki=3.7 μM) 处显示负调节活性，并充当 GABAA 受体的负调节剂。Flindokalner 在体内显示出抗焦虑功效。

靶点

Ki: 3.7 μM (Kv7.1), 230 μM (Kv7.4), 605 μM (Kv7.5)

体外研究

Flindokalner (BMS-204352) (10 μM) inhibits Kv7.4and Kv7.5 with K _i s of 230 and 605 μM, respectively.
Flindokalner (1-10 μM) causes inhibition of the Ca ²⁺ current in a dose-dependent manner, with a Kd of 6 μM and a Hill coefficient of 1.33. Flindokalnerinhibits cardiac L-type Ca ²⁺ channels in a direct manner, without affecting BKCa channels or intracellular signal transduction, in freshly isolated rat ventricular myocytes.

体内研究

Flindokalner (BMS-204352) (3-30 mg/kg; i.p.) induces a dose-dependent anxiolytic effect.
In shock-based conditioned model of anxiety in male Wistar rats, Flindokalner (3-60 mg/kg; i.p.) engenderes an anxiolytic profile.

Animal Model:	Female NMRI or male C57 mice (20-25 g) (Anxiolytic Models)
Dosage:	i.p.
Administration:	3, 10, 30 mg/kg
Result:	Significantly and dose dependently increased time spent in the open areas, reduced latency to enter an open area, and increased the number of entries in to the open areas in Zero Maze.

安全信息

WGK Germany	WGK 3
存储类别	11 - 可燃固体
危险性类别	眼部刺激类别2 经皮刺激类别2 特异性靶器官毒性-一次接触，类别3

MSDS信息

(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one 价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2026/06/05	HY-108584	Flindokalner	187523-35-9	1 mg	421元
2026/06/05	HY-108584	(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one Flindokalner	187523-35-9	5mg	960元

(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one