麦冬高异黄酮A
| 中文名称 | 麦冬高异黄酮A |
|---|---|
| 中文同义词 | 甲基麦冬二氢高异黄酮A;甲基麦冬黄烷酮A;麦冬高异黄酮A,甲基麦冬黄烷酮A;甲基麦冬二氢高异黄酮A,甲基麦冬黄烷酮A;麦冬甲基黄烷酮A;甲基麦冬二氢高异黄酮A(麦冬高异黄酮A,甲基麦冬黄烷酮A);甲基麦冬二氢高异黄酮A(麦冬高异黄酮A;麦冬高异黄酮A |
| 英文名称 | Methylophiopogonanone A |
| 英文同义词 | Methylophiopogonanone A;(3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one;Methylophiopogonanone A(R-Methylophiopogonanone A);8-Methylophiopogonanone A;(3R)-3-(1,3-Benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-4H-1-benzopyran-4-one;R-Methylophiopogonanone A;Methylophiopogonanone A (MO-A);4H-1-Benzopyran-4-one, 3-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-, (3R)- |
| CAS号 | 74805-92-8 |
| 分子式 | C19H18O6 |
| 分子量 | 342.34 |
| EINECS号 | |
| 相关类别 | 分析试剂标准品;植物提取物;对照品;植提标准品;中药对照品;标准品;标准品-中药标准品;黄酮;标准品 -中药标准品;标准品，对照品;标准品-对照品;杂质对照品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
| Mol文件 | 74805-92-8.mol |
| 结构式 |  |
麦冬高异黄酮A 性质
| 沸点 | 580.1±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.410 |
| 储存条件 | 2-8°C |
| 溶解度 | 溶于氯仿、甲醇； |
| 形态 | 粉末 |
| 酸度系数(pKa) | 8.24±0.40(Predicted) |
| 颜色 | 浅黄色 |
| 水溶解性 | insoluble in water |
| InChI | 1S/C19H18O6/c1-9-16(20)10(2)19-15(17(9)21)18(22)12(7-23-19)5-11-3-4-13-14(6-11)25-8-24-13/h3-4,6,12,20-21H,5,7-8H2,1-2H3/t12-/m1/s1 |
| InChIKey | BXTNNJIQILYHJB-GFCCVEGCSA-N |
| SMILES | O=C1[C@H](CC2=CC=C(OCO3)C3=C2)COC4=C(C)C(O)=C(C)C(O)=C41 |
Methylophiopogonanone A 是从 Ophiopogon japonicas 提取到的黄酮类化合物，具有抗氧化和抗炎作用。
Methylophiopogonanone A (MO-A; 10 μmol/L) significantly decreases apoptosis and cleaved caspase-3 expression, elevated the Bcl-2/Bax ratio and restored NO production. Pretreatment with Methylophiopogonanone A (MO-A) markedly increases the activation of PI3K/Akt/eNOS pathway in H9C2 cells subjected to H/R, and the protective effects of MO-A are abolished in the presence of the PI3K inhibitor wortmannin (100 nmol/L).
Methylophiopogonanone A (MO-A;10 mg/kg/d, po) for 2 weeks) protects cardiac function following myocardial I/R injury.
化学性质
可溶于甲醇、乙醇、DMSO等有机溶剂，来源于麦冬须根Ophiopogon japonicus．。用途
甲基麦冬黄烷酮A具有提高蛋白酶活性，调节细胞骨架重建的作用。用途
含量测定/鉴定/药理实验等安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-N2437 | 麦冬高异黄酮A Methylophiopogonanone A | 74805-92-8 | 1 mg | 540元 |
| 2026/06/05 | HY-N2437 | 麦冬高异黄酮A Methylophiopogonanone A | 74805-92-8 | 5mg | 1234元 |