- Methylophiopogonanone A
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- $0.00 / 5mg
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2023-02-24
- CAS:74805-92-8
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
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| | Methylophiopogonanone A Basic information |
| Product Name: | Methylophiopogonanone A | | Synonyms: | Methylophiopogonanone A;(3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one;Methylophiopogonanone A(R-Methylophiopogonanone A);8-Methylophiopogonanone A;(3R)-3-(1,3-Benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-4H-1-benzopyran-4-one;R-Methylophiopogonanone A;Methylophiopogonanone A (MO-A);4H-1-Benzopyran-4-one, 3-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-, (3R)- | | CAS: | 74805-92-8 | | MF: | C19H18O6 | | MW: | 342.34 | | EINECS: | | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 74805-92-8.mol |  |
| | Methylophiopogonanone A Chemical Properties |
| Boiling point | 580.1±50.0 °C(Predicted) | | density | 1.410 | | storage temp. | 2-8°C | | solubility | Soluble in chloroform and methanol; | | form | powder | | pka | 8.24±0.40(Predicted) | | color | Light yellow | | Water Solubility | insoluble in water | | InChI | 1S/C19H18O6/c1-9-16(20)10(2)19-15(17(9)21)18(22)12(7-23-19)5-11-3-4-13-14(6-11)25-8-24-13/h3-4,6,12,20-21H,5,7-8H2,1-2H3/t12-/m1/s1 | | InChIKey | BXTNNJIQILYHJB-GFCCVEGCSA-N | | SMILES | O=C1[C@H](CC2=CC=C(OCO3)C3=C2)COC4=C(C)C(O)=C(C)C(O)=C41 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | Methylophiopogonanone A Usage And Synthesis |
| Description | Methylophiopogonanone A is a homoisoflavonoid that has been found in O. japonicus roots and has diverse biological activities. It increases the uptake of rosuvastatin (Item Nos. 12029 | 18813) and atorvastatin in HEK293T cells expressing human organic anion transporting polypeptide 1B1 (OATP1B1; EC50s = 11.33 and 6 μM, respectively). Methylophiopogonanone A scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and ABTS radicals in cell-free assays. In vivo, methylophiopogonanone A (10 mg/kg) decreases body weight gain and reduces serum and hepatic lipid levels in a rat model of high-fat diet-induced hyperlipidemia. It also reduces infarct size and myocardial apoptosis in mouse model of ischemia-reperfusion injury induced by transient occlusion of the left anterior descending coronary artery. | | Chemical Properties | It is soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from the hairy roots of Ophiopogon japonicus. | | Uses | Methylophiopogonanone A, a major homoisoflavonoid in Ophiopogon japonicas, has both anti-oxidative and anti-inflammatory properties[1]. | | Definition | ChEBI: Methylophiopogonanone A is a homoflavonoid. | | in vivo | Methylophiopogonanone A (MO-A;10 mg/kg/d, po) for 2 weeks) protects cardiac function following myocardial I/R injury[1]. | | target | MMP(e.g.TIMP) | | References | [1] He F, et al. Methylophiopogonanone A suppresses ischemia/reperfusion-induced myocardial apoptosis in mice via activating PI3K/Akt/eNOS signaling pathway. Acta Pharmacol Sin. 2016 Jun;37(6):763-71. DOI:10.1038/aps.2016.14 |
| | Methylophiopogonanone A Preparation Products And Raw materials |
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