| Company Name: |
Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136 |
| Email: |
Sales@ATKchemical.com |
| Products Intro: |
Product Name:1(4H)-Cycloheptapyrazoleacetic acid, 5,6,7,8-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, ethyl ester
CAS:2765255-93-2
Purity:98% Package:50MG;100MG,1G,5G,100G
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| Company Name: |
ShangHai ChuanQian Chemcial Technique Centre
|
| Tel: |
15869524721 |
| Email: |
3525679403@qq.com |
| Products Intro: |
Product Name:1(4H)-Cycloheptapyrazoleacetic acid, 5,6,7,8-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, ethyl ester
CAS:2765255-93-2
Package:5g
|
| Company Name: |
Bide Pharmatech Ltd.
|
| Tel: |
400-1647117 13681763483 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:Ethyl 2-(3-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydrocyclohepta[c]pyrazol-1(4H)-yl)acetate
CAS:2765255-93-2
Purity:98% Package:10mg;25mg;50mg;100mg Remarks:BD02143092
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1(4H)-Cycloheptapyrazoleacetic acid, 5,6,7,8-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, ethyl ester manufacturers
- JNJ-28583113
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- $84.00 / 1mg
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2025-10-03
- CAS:2765255-93-2
- Min. Order:
- Purity: 98.57%
- Supply Ability: 10g
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| | 1(4H)-Cycloheptapyrazoleacetic acid, 5,6,7,8-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, ethyl ester Basic information |
| Product Name: | 1(4H)-Cycloheptapyrazoleacetic acid, 5,6,7,8-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, ethyl ester | | Synonyms: | 1(4H)-Cycloheptapyrazoleacetic acid, 5,6,7,8-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, ethyl ester;Ethyl 2-(3-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydrocyclohepta[c]pyrazol-1(4H)-yl)acetate | | CAS: | 2765255-93-2 | | MF: | C19H21F3N2O2 | | MW: | 366.38 | | EINECS: | | | Product Categories: | | | Mol File: | 2765255-93-2.mol | ![1(4H)-Cycloheptapyrazoleacetic acid, 5,6,7,8-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, ethyl ester Structure](CAS/20210305/GIF/2765255-93-2.gif) |
| | 1(4H)-Cycloheptapyrazoleacetic acid, 5,6,7,8-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, ethyl ester Chemical Properties |
| Boiling point | 462.2±45.0 °C(Predicted) | | density | 1.28±0.1 g/cm3(Predicted) | | form | Solid | | pka | 1.52±0.20(Predicted) | | color | White to off-white |
| | 1(4H)-Cycloheptapyrazoleacetic acid, 5,6,7,8-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, ethyl ester Usage And Synthesis |
| Uses | JNJ-28583113 is an TRPM2 antagonist with brain permeability. JNJ-28583113 inhibits TRPM2 blocked phosphorylation of GSK3α and β subunits. JNJ-28583113 protects cells from oxidative stress induced cell death. JNJ-28583113 also suppresses cytokine release in response to pro-inflammatory stimuli in microglia[1]. | | in vivo | JNJ-28583113 (10 mg/kg, 2?ml/kg; sc; single dose) is brain penetrant, and achieves 400?ng/mL in the brain compartment[1]. | Animal Model: | Harlan Sprague Dawley Rats (400 g)[1] | | Dosage: | 10 mg/kg, 2?mL/kg | | Administration: | SC; sampled at 0.5, 2, or 6?h post dosing | | Result: | Quickly metabolized in the plasma, while it showed high levels in plasma and low levels in the brain. |
| | IC 50 | TRPM2 | | References | [1] Fourgeaud L, et al. Pharmacology of JNJ-28583113: A novel TRPM2 antagonist. Eur J Pharmacol. 2019 Jun 15;853:299-307. DOI:10.1016/j.ejphar.2019.03.043 |
| | 1(4H)-Cycloheptapyrazoleacetic acid, 5,6,7,8-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, ethyl ester Preparation Products And Raw materials |
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