Acetamide, 2-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-6,7-dimethoxy-2-quinazolinyl]sulfinyl]-N-(4-cyanophenyl)-

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Acetamide, 2-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-6,7-dimethoxy-2-quinazolinyl]sulfinyl]-N-(4-cyanophenyl)- Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:HIV-1 inhibitor-23
CAS:2554622-28-3
Package:25mg;1520USD|100mg;2500USD|50mg;1980USD
Company Name: Nantong Hanfang Biotechnology Co. , Ltd.  
Tel: hanfangpharma@126.com; 18616537568
Email: hanfangpharma@126.com
Products Intro: CAS:2554622-28-3
Purity:98% HPLC Package:10mg;1g;10g;100g;1kg
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:HIV-1 inhibitor-23
CAS:2554622-28-3
Package:25mg/RMB 10600;100mg/RMB 17500;50mg/RMB 13800

Acetamide, 2-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-6,7-dimethoxy-2-quinazolinyl]sulfinyl]-N-(4-cyanophenyl)- manufacturers
Acetamide, 2-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-6,7-dimethoxy-2-quinazolinyl]sulfinyl]-N-(4-cyanophenyl)- Basic information
Product Name:Acetamide, 2-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-6,7-dimethoxy-2-quinazolinyl]sulfinyl]-N-(4-cyanophenyl)-
Synonyms:Acetamide, 2-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-6,7-dimethoxy-2-quinazolinyl]sulfinyl]-N-(4-cyanophenyl)-;HIV-1 inhibitor-23
CAS:2554622-28-3
MF:C30H26N6O4S
MW:566.63
EINECS:
Product Categories:
Mol File:2554622-28-3.mol
Acetamide, 2-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-6,7-dimethoxy-2-quinazolinyl]sulfinyl]-N-(4-cyanophenyl)- Structure
Acetamide, 2-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-6,7-dimethoxy-2-quinazolinyl]sulfinyl]-N-(4-cyanophenyl)- Chemical Properties
density 1.41±0.1 g/cm3(Predicted)
pka10.53±0.70(Predicted)
Safety Information
MSDS Information
Acetamide, 2-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-6,7-dimethoxy-2-quinazolinyl]sulfinyl]-N-(4-cyanophenyl)- Usage And Synthesis
UsesHIV-1 inhibitor-23 (compound 12a) is a highly potent HIV-1 non-nucleoside reverse transcriptase inhibitor, with EC50s of 24.9 nM and 10.4 nM for HIV-1 WT and HIV-1 K103N, respectively. HIV-1 inhibitor-23 has low cytotoxicity (CC50>221μM) and a favorable in vitro microsomal stability[1].
IC 50HIV-1 (WT): 24.9 nM (EC50); HIV-1 (K103N): 10.4 nM (EC50)
References[1] Han S, et al. Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors. Eur J Med Chem. 2020;185:111874. DOI:10.1016/j.ejmech.2019.111874
Acetamide, 2-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-6,7-dimethoxy-2-quinazolinyl]sulfinyl]-N-(4-cyanophenyl)- Preparation Products And Raw materials
Tag:Acetamide, 2-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-6,7-dimethoxy-2-quinazolinyl]sulfinyl]-N-(4-cyanophenyl)-(2554622-28-3) Related Product Information