| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:HDAC8/BRPF1-IN-1
CAS:2484255-85-6
Package:50mg/RMB 13800;25mg/RMB 10600;100mg/RMB 17500
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Benzamide, 3-[[(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)amino]sulfonyl]-N-hydroxy-4-methoxy- manufacturers
- HDAC8/BRPF1-IN-1
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- $1980.00
-
2026-05-11
- CAS:2484255-85-6
- Purity:
- Supply Ability: 10g
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| | Benzamide, 3-[[(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)amino]sulfonyl]-N-hydroxy-4-methoxy- Basic information |
| | Benzamide, 3-[[(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)amino]sulfonyl]-N-hydroxy-4-methoxy- Chemical Properties |
| density | 1.441±0.06 g/cm3(Predicted) | | pka | 8.38±0.20(Predicted) |
| | Benzamide, 3-[[(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)amino]sulfonyl]-N-hydroxy-4-methoxy- Usage And Synthesis |
| Uses | HDAC8/BRPF1-IN-1 (Compound 23a) is a dual inhibitor of HDAC8 and BRPF1 with an IC50 of 443 nM against human HDAC8 and a Kd of 67 nM against human BRPF1. HDAC8/BRPF1-IN-1 shows low in vitro activity against HDAC1 and 6[1]. | | IC 50 | hHDAC8: 443 nM (IC50); hBRPF1: 67 nM (Ki) | | References | [1] Ghazy E, et al. Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1. Eur J Med Chem. 2020 Aug 15;200:112338. DOI:10.1016/j.ejmech.2020.112338 |
| | Benzamide, 3-[[(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)amino]sulfonyl]-N-hydroxy-4-methoxy- Preparation Products And Raw materials |
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