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| | 1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(R)-(9CI) Basic information |
| Product Name: | 1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(R)-(9CI) | | Synonyms: | 1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(R)-(9CI);(R)-3-(Methylamino)pyrrolidine-1-carboxylic acid tert-butyl ester;tert-Butyl (3R)-3-(methylamino)pyrrolidine-1-carboxylate;(R)-1-Boc-3-(Methylamino)pyrrolidinehydrochloride;(R)-1-Boc-3-(methylamino)pyrrolidine HCl;(S)-1-Boc-3-methylaminopyrrolidine, hydrochloride;1-N-Boc-3-(R)-(Methylamino) pyrrolidine;(R)-benzyl 3-(methylamino)pyrrolidine-1-carboxylate | | CAS: | 199336-83-9 | | MF: | C10H20N2O2 | | MW: | 200.28 | | EINECS: | | | Product Categories: | AMINOACID | | Mol File: | 199336-83-9.mol |  |
| | 1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(R)-(9CI) Chemical Properties |
| Boiling point | 269 ºC | | density | 1.03 | | Fp | 117 ºC | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 10.02±0.20(Predicted) | | Appearance | Colorless to light yellow Liquid |
| RIDADR | UN2735 | | HS Code | 2933998090 |
| | 1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(R)-(9CI) Usage And Synthesis |
| Synthesis | Step 7-2: 1.18 g of (R)-1-(tert-butoxycarbonyl)-3-methylaminopyrrolidine hydrochloride (chemical purity: 99.9 area%) was mixed with 2.30 g of 23 wt. % brine, 4.71 g of toluene and 734 mg of 30 wt. % aqueous sodium hydroxide solution, and was prepared in accordance with the methodology described in Step 7-1. After stirring the reaction mixture, a partitioning operation was carried out. The organic layer was concentrated and dried under vacuum to give 946 mg of tert-butyl (R)-3-(methylamino)pyrrolidine-1-carboxylate as a colorless, transparent liquid (chemical purity: 99.3 area%, yield 97%).1H-NMR (CDCl3) data: δ (ppm) 1.45 (s, 9H), 1.71 (m, 2H), 2.04 (m, 1H). 2.44 (s, 3H), 3.03-3.28 (m, 2H), 3.29-3.65 (m, 3H). | | References | [1] Patent: EP2050735, 2009, A1. Location in patent: Page/Page column 20 |
| | 1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(R)-(9CI) Preparation Products And Raw materials |
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