2-Butenoic acid, 4-[[3-(aminocarbonyl)phenyl]amino]-4-oxo-, methyl ester, (2Z)-

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2-Butenoic acid, 4-[[3-(aminocarbonyl)phenyl]amino]-4-oxo-, methyl ester, (2Z)- Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:ARTD10/PARP10-IN-1
CAS:1708103-76-7
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:ARTD10/PARP10-IN-1
CAS:1708103-76-7
Purity:99.14% Package:1mg;350USD|5mg;970USD|25mg;1460USD
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
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Products Intro: Product Name:ARTD10/PARP10-IN-1
CAS:1708103-76-7
Purity:98% Package:5mg Remarks:S34065
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
Tel: 15076683720
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Products Intro: Product Name:ARTD10/PARP10-IN-1
CAS:1708103-76-7
Purity:大于98% Remarks:Not For Human Use, Lab Use Only.
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Products Intro: CAS:1708103-76-7
Purity:98 Package:1G,5G,10G,50G,100G,500G

2-Butenoic acid, 4-[[3-(aminocarbonyl)phenyl]amino]-4-oxo-, methyl ester, (2Z)- manufacturers
2-Butenoic acid, 4-[[3-(aminocarbonyl)phenyl]amino]-4-oxo-, methyl ester, (2Z)- Basic information
Product Name:2-Butenoic acid, 4-[[3-(aminocarbonyl)phenyl]amino]-4-oxo-, methyl ester, (2Z)-
Synonyms:2-Butenoic acid, 4-[[3-(aminocarbonyl)phenyl]amino]-4-oxo-, methyl ester, (2Z)-;ARTD10/PARP10-IN-1;PARP10-IN-1
CAS:1708103-76-7
MF:C12H12N2O4
MW:248.23
EINECS:
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Mol File:1708103-76-7.mol
2-Butenoic acid, 4-[[3-(aminocarbonyl)phenyl]amino]-4-oxo-, methyl ester, (2Z)- Structure
2-Butenoic acid, 4-[[3-(aminocarbonyl)phenyl]amino]-4-oxo-, methyl ester, (2Z)- Chemical Properties
Boiling point 495.3±45.0 °C(Predicted)
density 1.321±0.06 g/cm3(Predicted)
pka11.28±0.70(Predicted)
Safety Information
MSDS Information
2-Butenoic acid, 4-[[3-(aminocarbonyl)phenyl]amino]-4-oxo-, methyl ester, (2Z)- Usage And Synthesis
UsesARTD10/PARP10-IN-1 (compound 23) is a potent and non-selective PARP inhibitor, targeting to mono-ADP-ribosyltransferases ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10 and poly(ADP-ribose) polymerase-1 (ARTD1/PARP1) with IC50s of 1.7 μM, 1.6 μM, 0.8 μM, and 4.4 μM, respectively[1].
IC 50ARTD1/PARP1: 4.4 μM (IC50); ARTD10/PARP10: 0.8 μM (IC50); ARTD8/PARP14: 1.6 μM (IC50); ARTD7/PARP15: 1.7 μM (IC50)
References[1] Ekblad T, et al. Towards small molecule inhibitors of mono-ADP-ribosyltransferases. Eur J Med Chem. 2015 May 5;95:546-51. DOI:10.1016/j.ejmech.2015.03.067
2-Butenoic acid, 4-[[3-(aminocarbonyl)phenyl]amino]-4-oxo-, methyl ester, (2Z)- Preparation Products And Raw materials
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