- Benidipine
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- $2785.00 / 50mg
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2026-01-05
- CAS:105979-17-7
- Min. Order:
- Purity:
- Supply Ability: 10g
- Benidipine
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- $15.00 / 1KG
-
2021-07-13
- CAS:105979-17-7
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- Benidipine
-
- $15.00 / 1KG
-
2021-07-10
- CAS:105979-17-7
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | Benidipine Basic information |
| Product Name: | Benidipine | | Synonyms: | (R*,R*)-(±)-(3,5-Pyridinedicarboxylic acid 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-methyl 1- (phenylmethyl)-3-piperidinyl ester monohydrochloride;3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl5-[(3R)-1-(phenylMethyl)-3-piperidinyl] ester, (4R)-rel-;NACADIPINE;BENIDIPINE;BENIDIPINE HCL;CAPADIPINE;CONIEL;KW-3049 | | CAS: | 105979-17-7 | | MF: | C28H31N3O6 | | MW: | 505.56 | | EINECS: | 857-680-4 | | Product Categories: | Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical | | Mol File: | 105979-17-7.mol |  |
| | Benidipine Chemical Properties |
| Boiling point | 625.2±55.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | pka | pKa 7.34(H2O(long extrapolation)
) (Uncertain) | | Water Solubility | 316μg/L at 25℃ | | InChIKey | QZVNQOLPLYWLHQ-GRHWAJSLNA-N | | SMILES | [C@H]1(C(C(=O)OC)=C(NC(C)=C1C(=O)O[C@@H]1CCCN(CC2=CC=CC=C2)C1)C)C1=CC=CC([N+]([O-])=O)=C1 |&1:0,14,r| | | LogP | 4.61 | | CAS DataBase Reference | 105979-17-7(CAS DataBase Reference) |
| | Benidipine Usage And Synthesis |
| Uses | Benidipine (CAS# 105979-17-7) is a 1,4-dihydropyridine and a calcium channel antagonist. Antihypertensive. | | in vivo | Benidipine (3, 5, 10 μg/kg; i.v.) shows significant anti-apoptosis effects in a haemodynamically independent manner[2].
Benidipine (5 mg/kg; i.v.; every other day for 6 weeks) increases the activity of endothelial cell-type nitric oxide synthase (eNOS) and improves coronary circulation in hypertensive rats[3].
Benidipine (1, 3, 10 mg/kg; p.o.; once daily for 1 week) significant cardioprotective effects against ischemia-reperfusion injury[4]. | Animal Model: | Sham MI (myocardial ischaemia)/R (ischmia reperfused injury) rabbits and MI/R rabbits[2] | | Dosage: | 3, 5, 10 μg/kg | | Administration: | I.v. | | Result: | Caused a significant decreased in HR ( heart rate), MABP (mean arterial blood pressure), PRI (pressure-rateindex) at 10 μg/kg, decreased apoptotic positive cells to7.4% at 3 μg/kg and not significantly different from that seen in the group treated with higher dose. |
| Animal Model: | Renovascular hypertensive rats (RHR)[3] | | Dosage: | 5 mg/kg (dissolved in peanut oil) | | Administration: | I.v.; every other day for 6 weeks | | Result: | Significantly decreased the blood pressure and coronary vascular resistance index, but increased nitrite production and eNOS mRNA expression and significantly increased the coronary flow at rest, the capillary density. |
| Animal Model: | Rats (heart model (Langendorff perfusion))[4] | | Dosage: | 1, 3, 10 mg/kg | | Administration: | P.o.; once daily for 1 week | | Result: | Significantly increased the post-ischemic recovery of LVDP and LV dP/dt max (LVDP: 87.5±10.1 vs 64.6±11.9%; LV dP/dt max: 97.8±10.4 vs 70.2±15.7%; p<0.05) at 3 mg/kg. |
| | Enzyme inhibitor | This oral, once-daily antihypertensive agent (FW = 505.57 g/mol; CAS 105979-17-7), also known by its code name KW-3049, trade name Coniel?, and systematic name O -methyl,O -[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, is a dihydropyridine-class calcium ion blocker that is effective against L-, N-, and T-channels, with potent and selective inhibitory action on cardiac slow calcium channels. Benidipine bound stereospecifically to nitrendipine binding sites of rat myocardium with high affinity (Ki = 0.13 nM) and to the rat brain a1-adrenergic receptor (Ki = 1.2 μM). KW-3049 exhibited no remarkable binding affinity to a2 adrenergic, b-adrenergic, D2 dopamine, H1 histamine, S2 serotonin, A1 adenosine, A2 adenosine and muscarinic cholinergic receptors at 100 μM. |
| | Benidipine Preparation Products And Raw materials |
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