N(4)-hydroxycytidine manufacturers
- EIDD-1931
-
- $76.00 / 5mg
-
2026-04-22
- CAS:3258-02-4
- Min. Order:
- Purity: 99.73%
- Supply Ability: 10g
- N(4)-hydroxycytidine
-
- $1.00 / 1KG
-
2024-07-11
- CAS:3258-02-4
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 20T
- N(4)-hydroxycytidine
-
- $9.90 / 10g
-
2022-02-23
- CAS:3258-02-4
- Min. Order: 10g
- Purity: 99.99%HPLC.USP42
- Supply Ability: 1000kgs
|
| Product Name: | N(4)-hydroxycytidine | | Synonyms: | N(4)-hydroxycytidine;1-[(2R)-3α,4α-Dihydroxy-5β-(hydroxymethyl)oxolane-2β-yl]-4-(hydroxyamino)pyrimidine-2(1H)-one;3,4-Dihydro-1-β-D-ribofuranosyl-4-(hydroxyimino)pyrimidin-2(1H)-one;N-Hydroxycytidine;β-D-N4-Hydroxycytidine;Beta-d-N4-hydroxycytidine;EIDD-1931;Beta-d-N4-hydroxycytidine
(NHC) | | CAS: | 3258-02-4 | | MF: | C9H13N3O6 | | MW: | 259.22 | | EINECS: | | | Product Categories: | | | Mol File: | 3258-02-4.mol |  |
| | N(4)-hydroxycytidine Chemical Properties |
| Melting point | 169-172 °C(Solv: methanol (67-56-1)) | | density | 1.93±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | Soluble in DMSO (up to 25 mg/ml) or in Water (up to 15 mg/ml with warming). | | pka | 8.19±0.20(Predicted) | | form | solid | | color | White | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. | | InChI | InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6-,7-,8-/m1/s1 | | InChIKey | XCUAIINAJCDIPM-XVFCMESISA-N | | SMILES | OC[C@H]1O[C@@H](N2C=CC(=NO)NC2=O)[C@H](O)[C@@H]1O |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | N(4)-hydroxycytidine Usage And Synthesis |
| Description | EIDD-1931 is a ribonucleoside analog with antiviral activity. It inhibits replication of severe acute respiratory syndrome coronavirus (SARS-CoV) in Vero 76 cells, Middle East respiratory syndrome coronavirus (MERS-CoV) in Calu-3 2B4 cells, and SARS-CoV-2 in Vero cells (IC50s =0.1, 0.15 and 0.3 μM, respectively). It also reduces viral titers of Venezuelan equine encephalitis virus (VEEV) TC-83 in infected Vero cells (EC50 = 0.426 μM) and wild-type and remdesivir-resistant strains of the model CoV mouse hepatitis virus (MHV) in infected DBT cells. EIDD-1931 (100 and 400 mg/kg twice per day) reduces lung viral titers in mouse models of respiratory syncytial virus (RSV) and H1N1 influenza A virus infection. | | Uses | EIDD 1931 is an orally bioavailable broad-spectrum antiviral that inhibits SARS-CoV-2 and other multiple endemic, epidemic and bat coronavirus and has the potential for seasonal and pandemic influenza treatment. A broad-spectrum ribonucleoside analog inhibitor of influenza and respiratory syncytial viruses. | | Definition | ChEBI: N(4)-hydroxycytidine is a nucleoside analogue that is cytidine which carries a hydroxy group at the N(4)-positon. It has broad-spectrum antiviral activity against influenza, SARS-CoV , SARS-CoV-2 and MERS-CoV. It has a role as a drug metabolite, a human xenobiotic metabolite, an anticoronaviral agent and an antiviral agent. It is a nucleoside analogue and a ketoxime. It is functionally related to a cytidine. | | storage | Store at -20°C | | Background | Beta-d-N4-Hydroxycytidine, also known as EIDD-1931, is a nucleic acid base analog and a specific AT to GC mutagen formed by the treatment of nucleoside cytidine with hydroxylamine. Beta-d-N4-Hydroxycytidine acts as a competitive substrate for viral encoded RNA polymerase and has demonstrated broad in vitro antiviral activity, including Chikungunya virus, Ebola, and Hepatitis C. Beta-d-N4-Hydroxycytidine demonstrated an IC50 value of 0.1 µM and an IC90 value of 6 µM in SARS-CoV infected Vero cells. | | References | [1] CELINA JANION Barry W G. N4-hydroxycytidine: A mutagen specific for at to GC transitions[J]. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 1980, 72 1: Pages 43-47. DOI:10.1016/0027-5107(80)90218-3
[2] LIEVEN J STUYVER. Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.[J]. Antimicrobial Agents and Chemotherapy, 2003, 47 1: 244-254. DOI:10.1128/aac.47.1.244-254.2003
[3] VERÓNICA P COSTANTINI. Antiviral activity of nucleoside analogues against norovirus.[J]. Antiviral Therapy, 2012, 17 6: 981-991. DOI:10.3851/imp2229
[4] O. REYNARD. Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication[J]. Viruses-Basel, 2015, 7 1: 6233-6240. DOI:10.3390/v7122934
[5] M. EHTESHAMI. Characterization of β-d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus[J]. Antimicrobial Agents and Chemotherapy, 2017. DOI:10.1128/aac.02395-16
[6] JEONG-JOONG YOON. Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses.[J]. Antimicrobial Agents and Chemotherapy, 2018, 62 8. DOI:10.1128/aac.00766-18
[7] DALE L BARNARD. Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and beta-D-N4-hydroxycytidine.[J]. Antiviral Chemistry and Chemotherapy, 2004, 15 1: 15-22. DOI:10.1177/095632020401500102
[8] KRZYSZTOF PYRC. Inhibition of human coronavirus NL63 infection at early stages of the replication cycle.[J]. Antimicrobial Agents and Chemotherapy, 2006: 2000-2008. DOI:10.1128/aac.01598-05
[9] MART TOOTS. Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia[J]. Science Translational Medicine, 2019, 11 515. DOI:10.1126/scitranslmed.aax5866 |
| | N(4)-hydroxycytidine Preparation Products And Raw materials |
|