2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[[(1S,2S)-2-(3-phenyl-1-azetidinyl)cyclohexyl]oxy]-2H-isoindol-2-yl]-, (3S)-

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2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[[(1S,2S)-2-(3-phenyl-1-azetidinyl)cyclohexyl]oxy]-2H-isoindol-2-yl]-, (3S)- Suppliers list
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2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[[(1S,2S)-2-(3-phenyl-1-azetidinyl)cyclohexyl]oxy]-2H-isoindol-2-yl]-, (3S)- Basic information
Product Name:2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[[(1S,2S)-2-(3-phenyl-1-azetidinyl)cyclohexyl]oxy]-2H-isoindol-2-yl]-, (3S)-
Synonyms:2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[[(1S,2S)-2-(3-phenyl-1-azetidinyl)cyclohexyl]oxy]-2H-isoindol-2-yl]-, (3S)-;(S)-3-(1-oxo-5-(((1S,2S)-2-(3-phenylazetidin-1-yl)cyclohexyl)oxy)isoindolin-2-yl)piperidine-2,6-dione;IKZF2 (zinc finger transcription factor Helios) degrader PLX-4545;PLX-4545
CAS:2892065-45-9
MF:C28H31N3O4
MW:473.56
EINECS:
Product Categories:
Mol File:2892065-45-9.mol
2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[[(1S,2S)-2-(3-phenyl-1-azetidinyl)cyclohexyl]oxy]-2H-isoindol-2-yl]-, (3S)- Structure
2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[[(1S,2S)-2-(3-phenyl-1-azetidinyl)cyclohexyl]oxy]-2H-isoindol-2-yl]-, (3S)- Chemical Properties
Boiling point 726.7±60.0 °C(Predicted)
density 1.309±0.06 g/cm3(Predicted)
pka10.78±0.40(Predicted)
Safety Information
MSDS Information
2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[[(1S,2S)-2-(3-phenyl-1-azetidinyl)cyclohexyl]oxy]-2H-isoindol-2-yl]-, (3S)- Usage And Synthesis
UsesPLX-4545 is an orally available, cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios), which can reprogram immunosuppressive regulatory T cells into pro-inflammatory effector T cells, thereby enhancing anti-tumor immune responses[1].
2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[[(1S,2S)-2-(3-phenyl-1-azetidinyl)cyclohexyl]oxy]-2H-isoindol-2-yl]-, (3S)- Preparation Products And Raw materials
Tag:2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[[(1S,2S)-2-(3-phenyl-1-azetidinyl)cyclohexyl]oxy]-2H-isoindol-2-yl]-, (3S)-(2892065-45-9) Related Product Information
Thalidomide Indisulam 2,6-Piperidinedione, 3-[5-(1,2-benzisoxazol-3-ylamino)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- VVD-130037 3-(2-chloro-4'-(2-oxopyridin-1(2H)-yl)-[1,1'-biphenyl]-3-yl)piperidine-2,6-dione CC-885