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| | factor 420 Basic information |
| Product Name: | factor 420 | | Synonyms: | factor 420;Coenzyme FO;enzyme FO;7,8-didemethyl-8-hydroxy-5-deazariboflavin | | CAS: | 37333-48-5 | | MF: | C16H17N3O7 | | MW: | 363.32208 | | EINECS: | | | Product Categories: | | | Mol File: | 37333-48-5.mol |  |
| | factor 420 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: 5 mg/mL (13.76 mM) | | form | Solid | | color | Yellow to brown |
| | factor 420 Usage And Synthesis |
| Uses | Coenzyme FO, a deazaflavin chromophore, acts as an important hydride acceptor/donor in the central methanogenic pathway[1][2]. | | Definition | ChEBI: Riboflavin in which the nitrogen at position 5 is replaced by CH and the methyl groups at positions 7 and 8 are substituted by hydrogen and hydroxy, respectively. | | References | [1] Mills DJ, et al. De novo modeling of the F(420)-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy. Elife. 2013;2:e00218. Published 2013 Mar 5. DOI:10.7554/eLife.00218
[2] Philmus B, et al. Biosynthetic versatility and coordinated action of 5'-deoxyadenosyl radicals in deazaflavin biosynthesis. J Am Chem Soc. 2015;137(16):5406-5413. DOI:10.1021/ja513287k
[3] de Poorter LMI, et al. Hydrogen concentrations in methane-forming cells probed by the ratios of reduced and oxidized coenzyme F420. Microbiology. 2005;151(Pt 5):1697‐1705. DOI:10.1099/mic.0.27679-0
[4] Purwantini E, et al. Conversion of NO2 to NO by reduced coenzyme F420 protects mycobacteria from nitrosative damage. Proc Natl Acad Sci U S A. 2009;106(15):6333‐6338. DOI:10.1073/pnas.0812883106 |
| | factor 420 Preparation Products And Raw materials |
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