- Telmisartan Intermediate
-
- $0.00 / 2Kg/Bag
-
2026-01-27
- CAS:152628-03-0
- Min. Order: 2Kg/Bag
- Purity: 99% up, High Density
- Supply Ability: 20 tons
|
| | 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Basic information |
| | 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Chemical Properties |
| Melting point | 300 °C | | Boiling point | 491.8±25.0 °C(Predicted) | | density | 1.259±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO, Methanol | | pka | 3.19±0.30(Predicted) | | form | Powder | | color | Pale Yellow to Tan | | InChIKey | XWAJTVCEILFDGU-UHFFFAOYSA-N | | CAS DataBase Reference | 152628-03-0(CAS DataBase Reference) |
| | 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Usage And Synthesis |
| Chemical Properties | Light Yellow to Tan Powder | | Uses | 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid is a useful synthetic intermediate,a useful compound in organic synthesis. | | Synthesis | Example 4: Methyl 3-methyl-4-butyrylamino-5-nitrobenzoate (II) (10 g, 0.036 mol) was suspended in 60 ml of water and heated to 70-80 °C. A suspension of sodium dithionite (21.75 g, 0.124 mol) in 60 ml of water was added slowly and heated to 90-100 °C. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 10-11 and the temperature was maintained with continued stirring until TLC detection showed complete disappearance of methyl 3-methyl-4-butyrylamino-5-nitrobenzoate. Subsequently, the pH of the reaction mixture was adjusted to 6-6.5. The resulting solid was filtered and dried at 45-50 °C to afford 2-n-propyl-4-methyl-6-carboxybenzimidazole (7.5 g, yield: 96.4%). | | References | [1] Patent: WO2012/28925, 2012, A2. Location in patent: Page/Page column 18
[2] Journal of Heterocyclic Chemistry, 2003, vol. 40, # 6, p. 1107 - 1112
[3] Journal of Medicinal Chemistry, 1993, vol. 36, # 25, p. 4040 - 4051
[4] Patent: WO2012/28925, 2012, A2
[5] Organic Process Research and Development, 2007, vol. 11, # 1, p. 81 - 85 |
| | 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Preparation Products And Raw materials |
|