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BOC Sciences |
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16314854226 |
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| | sesaminol Basic information |
| Product Name: | sesaminol | | Synonyms: | (1S,3aβ,6aβ)-1β-(6-Hydroxy-1,3-benzodioxol-5-yl)-4β-(1,3-benzodioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan;sesaminol;6-[(1S,3aR,4S,6aR)-4-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-1-yl]-1,3-benzodioxol-5-ol;1,3-Benzodioxol-5-ol, 6-[(1S,3aR,4S,6aR)-4-(1,3-benzodioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]- | | CAS: | 74061-79-3 | | MF: | C20H18O7 | | MW: | 370.35 | | EINECS: | | | Product Categories: | | | Mol File: | 74061-79-3.mol |  |
| | sesaminol Chemical Properties |
| Boiling point | 504.7±50.0 °C(Predicted) | | density | 1.456±0.06 g/cm3(Predicted) | | pka | 9.69±0.20(Predicted) | | Cosmetics Ingredients Functions | SKIN CONDITIONING - MISCELLANEOUS |
| | sesaminol Usage And Synthesis |
| Uses | Sesaminol is an orally active activator for Nrf2-ARE pathway, that promotes the the nuclear translocation of Nrf2 and enhances the NQO1 expression, thereby enhances the cell's defense against oxidative stress. Sesaminol inhibits 6-OHDA (HY-B1081)-induced ROS production and apoptosis in cell SH-SY5Y. Sesaminol exhibits neuroprotective efficacy against Rotenone (HY-B1756)-induced Parkinson's disease[1]. | | Definition | ChEBI: Sesaminol is a furofuran that is cis-tetrahydro-1H,3H-furo[3,4-c]furan substituted by a 6-hydroxy-1,3-benzodioxol-5-yl group at position 1S and a 1,3-benzodioxol-5-yl group at position 4S. It is metabolite found in sesame seeds. It has a role as a plant metabolite and an antioxidant. It is a member of benzodioxoles, a furofuran and an organic hydroxy compound. | | References | [1] Kaji H, et al., Sesaminol prevents Parkinson's disease by activating the Nrf2-ARE signaling pathway. Heliyon. 2020 Nov 2;6(11):e05342. DOI:10.1016/j.heliyon.2020.e05342 |
| | sesaminol Preparation Products And Raw materials |
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