5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide

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5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide Basic information
Product Name:5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide
Synonyms:5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide;1H-Indazole-3-carboxamide, 5-[[4-[4-[(dimethylamino)methyl]-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]-N,1-dimethyl-
CAS:2932264-95-2
MF:C21H25N9O
MW:419.48
EINECS:
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Mol File:2932264-95-2.mol
5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide Structure
5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide Chemical Properties
density 1.354±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka12.925±0.46(predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide Usage And Synthesis
UsesSyk-IN-4 is a potent, selective and orally bioavailable SYK inhibitor with an IC50 of 0.31 nM. SYK has emerged as a potential target for autoimmunity and hematological cancers[1].
in vivo

Syk-IN-4 exhibits moderate oral bioavailability (60%) following oral administration (1 mg/kg) in male Hans Wistar rats[1].
Syk-IN-4 exhibits high plasma clearance (151 mL/min/kg) combined with large volumes of distribution (1.0 L/kg respectively) following i.v. administration (0.5 mg/kg) in male Hans Wistar rats[1].

References[1] Neil P Grimster, et al. Optimization of a Series of Potent, Selective and Orally Bioavailable SYK Inhibitors. Bioorg Med Chem Lett. 2020 Jul 24;127433. DOI:10.1016/j.bmcl.2020.127433
5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide Preparation Products And Raw materials
Tag:5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide(2932264-95-2) Related Product Information
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