Myosin-IN-1

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Myosin-IN-1 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Myosin-IN-1 Basic information
Product Name:Myosin-IN-1
Synonyms:Myosin-IN-1;Thiourea, N-(6-ethyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)-N′-(1-methylethyl)-
CAS:849011-39-8
MF:C12H16N4OS2
MW:296.41
EINECS:
Product Categories:
Mol File:849011-39-8.mol
Myosin-IN-1 Structure
Myosin-IN-1 Chemical Properties
Boiling point 442.208±47.00 °C(Press: 760.00 Torr)(predicted)
density 1.401±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka7.908±0.20(predicted)
Safety Information
MSDS Information
Myosin-IN-1 Usage And Synthesis
UsesMyosin-IN-1 (compound F10) is a Myosin inhibitor that specifically targets cardiac myosin. Myosin-IN-1 stabilizes the biochemical and structural closed state of the cardiac myosin motor domain and reduces myocardial force production and calcium sensitivity in vitro. Myosin-IN-1 acts as a negative inotropic agent in isolated Langendroff-perfused rat hearts, reducing stress in isolated myofilaments and left ventricular pressure development. Myosin-IN-1 can be used in heart failure research[1].
References[1] Parijat P, et al. Discovery of a novel cardiac-specific myosin modulator using artificial intelligence-based virtual screening. Nat Commun. 2023 Nov 24;14(1):7692. DOI:10.1038/s41467-023-43538-y
Myosin-IN-1 Preparation Products And Raw materials
Tag:Myosin-IN-1(849011-39-8) Related Product Information
Phenol, 2,4-dichloro-6-(3,4,5-trichloro-1H-pyrrol-2-yl)- 1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl- CK-586 W-7 Hydrochloride 4H-Pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-1-(2-methoxy-4-pyridinyl)-6,7-dimethyl-, (3aS)- Mavacamten