JAK1-IN-13

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JAK1-IN-13 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
JAK1-IN-13 Basic information
Product Name:JAK1-IN-13
Synonyms:JAK1-IN-13;1H-Pyrrolo[2,3-b]pyridine-5-carboxamide, N-methyl-4-[[(2S,4S)-2-methyl-1-[[4-(trifluoromethyl)phenyl]methyl]-4-piperidinyl]amino]-
CAS:2778330-90-6
MF:C23H26F3N5O
MW:445.48
EINECS:
Product Categories:
Mol File:2778330-90-6.mol
JAK1-IN-13 Structure
JAK1-IN-13 Chemical Properties
density 1.309±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka13.97±0.40(predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
JAK1-IN-13 Usage And Synthesis
UsesJAK1-IN-13 (compound 36b) is an orally active, potent and highly selective inhibitor of JAK1 with an IC50 of 0.044 nM. JAK1-IN-13 significantly decreases STAT3 phosphorylation[1].
References[1] Park E, et al. Identification and Biological Evaluation of a Potent and Selective JAK1 Inhibitor for the Treatment of Pulmonary Fibrosis. J Med Chem. 2023 Dec 14;66(23):16342-16363. DOI:10.1021/acs.jmedchem.3c01712
JAK1-IN-13 Preparation Products And Raw materials
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