7-Quinolinecarbonitrile, 1-[2-[4-[[(3,4-dihydro-3-oxo-2H-1,4-benzothiazin-6-yl)methyl]amino]-1-piperidinyl]ethyl]-1,2-dihydro-2-oxo-

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7-Quinolinecarbonitrile, 1-[2-[4-[[(3,4-dihydro-3-oxo-2H-1,4-benzothiazin-6-yl)methyl]amino]-1-piperidinyl]ethyl]-1,2-dihydro-2-oxo- Basic information
Product Name:7-Quinolinecarbonitrile, 1-[2-[4-[[(3,4-dihydro-3-oxo-2H-1,4-benzothiazin-6-yl)methyl]amino]-1-piperidinyl]ethyl]-1,2-dihydro-2-oxo-
Synonyms:7-Quinolinecarbonitrile, 1-[2-[4-[[(3,4-dihydro-3-oxo-2H-1,4-benzothiazin-6-yl)methyl]amino]-1-piperidinyl]ethyl]-1,2-dihydro-2-oxo-;Antibacterial agent 236
CAS:2364479-10-5
MF:C26H27N5O2S
MW:473.59
EINECS:
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Mol File:2364479-10-5.mol
7-Quinolinecarbonitrile, 1-[2-[4-[[(3,4-dihydro-3-oxo-2H-1,4-benzothiazin-6-yl)methyl]amino]-1-piperidinyl]ethyl]-1,2-dihydro-2-oxo- Structure
7-Quinolinecarbonitrile, 1-[2-[4-[[(3,4-dihydro-3-oxo-2H-1,4-benzothiazin-6-yl)methyl]amino]-1-piperidinyl]ethyl]-1,2-dihydro-2-oxo- Chemical Properties
Boiling point 705.3±60.0 °C(predicted)
density 1.38±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka12.86±0.20(predicted)
Safety Information
MSDS Information
7-Quinolinecarbonitrile, 1-[2-[4-[[(3,4-dihydro-3-oxo-2H-1,4-benzothiazin-6-yl)methyl]amino]-1-piperidinyl]ethyl]-1,2-dihydro-2-oxo- Usage And Synthesis
UsesAntibacterial agent 236 (Compound 4l) is an orally active inhibitor for DNA gyrase and topoisomerase IV (IC50 is 3.2 and 300 nM in Staphylococcus aureus), and exhibits board-spectrum antibacterial activity. Antibacterial agent 236 exhibits good pharmacokinetic properties in mice[1].
References[1] Desai J, et al., Discovery of aminopiperidine based potent & novel topoisomerase inhibitor with broad spectrum anti-bacterial activity. Bioorg Med Chem Lett. 2024 Oct 1;111:129911. DOI:10.1016/j.bmcl.2024.129911
7-Quinolinecarbonitrile, 1-[2-[4-[[(3,4-dihydro-3-oxo-2H-1,4-benzothiazin-6-yl)methyl]amino]-1-piperidinyl]ethyl]-1,2-dihydro-2-oxo- Preparation Products And Raw materials
Tag:7-Quinolinecarbonitrile, 1-[2-[4-[[(3,4-dihydro-3-oxo-2H-1,4-benzothiazin-6-yl)methyl]amino]-1-piperidinyl]ethyl]-1,2-dihydro-2-oxo-(2364479-10-5) Related Product Information
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