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| | AB25583 Basic information |
| Product Name: | AB25583 | | Synonyms: | AB25583;3-Pyridinecarboxamide, N-[5-[(4-chlorophenyl)methoxy]-1,3,4-thiadiazol-2-yl]-4-(2-methoxyphenyl)-;N-(5-((4-Chlorobenzyl)oxy)-1,3,4-thiadiazol-2-yl)-4-(2-methoxyphenyl)nicotinamide | | CAS: | 2565637-94-5 | | MF: | C22H17ClN4O3S | | MW: | 452.92 | | EINECS: | | | Product Categories: | | | Mol File: | 2565637-94-5.mol |  |
| | AB25583 Chemical Properties |
| density | 1.400±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 6.276±0.10(predicted) | | form | Solid | | color | White to off-white |
| | AB25583 Usage And Synthesis |
| Uses | AB25583 is a Polθ helicase (Polθ-hel) small molecule inhibitor, with an IC50 value of 6 nM. AB25583 selectively kills BRCA1/2 deficient cells and works in synergy with Olaparib (HY-10162) in cancer cells carrying pathogenic BRCA1/2 mutations. AB25583 can be used for tumor research[1]. | | References | [1] Ito F, et al. Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM. Nat Commun. 2024 Aug 14;15(1):7003. DOI:10.1038/s41467-024-51351-4 |
| | AB25583 Preparation Products And Raw materials |
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