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| | JWZ-7-7-Neg1 Basic information |
| Product Name: | JWZ-7-7-Neg1 | | Synonyms: | JWZ-7-7-Neg1;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, N-[7-[[[1-[5-chloro-4-[[1,2-dihydro-8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxo-6-quinolinyl]amino]-2-pyrimidinyl]-4-piperidinyl]carbonyl]amino]heptyl]-4-(4-chlorophenyl)-2,3,9-trimethyl-, (6R)- | | CAS: | 3008612-30-1 | | MF: | C50H58Cl2N12O6S | | MW: | 1026.05 | | EINECS: | | | Product Categories: | | | Mol File: | 3008612-30-1.mol |  |
| | JWZ-7-7-Neg1 Chemical Properties |
| density | 1.444±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| | JWZ-7-7-Neg1 Usage And Synthesis |
| Uses | JWZ-7-7-Neg1 is a transcriptional chemical inducers of proximity (TCIP) with negative chemical control. JWZ-7-7-Neg1 reduces the ability to bind to BRD4 or BCL6, so it has less cytotoxicity to DLBCL cells, in compared with JWZ-7-7[1]. | | References | [1] Crabtree GR, et al., Compositions, systems, and methods for modulating a target gene. WO2023215311. |
| | JWZ-7-7-Neg1 Preparation Products And Raw materials |
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