HDAC8-IN-12

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HDAC8-IN-12 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
HDAC8-IN-12 Basic information
Product Name:HDAC8-IN-12
Synonyms:HDAC8-IN-12;2-Propenamide, N-hydroxy-3-[2-methoxy-4-[(1-methyl-3,6-dioxo-2-piperazinylidene)methyl]phenyl]-
CAS:3028095-13-5
MF:C16H17N3O5
MW:331.32
EINECS:
Product Categories:
Mol File:3028095-13-5.mol
HDAC8-IN-12 Structure
HDAC8-IN-12 Chemical Properties
density 1.364±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka8.98±0.23(predicted)
Safety Information
MSDS Information
HDAC8-IN-12 Usage And Synthesis
UsesHDAC8-IN-12 (compound 5k) is a non-hydroxamic acid, selective inhibitor of HDAC8 (IC50: 0.12 nM) and a potent inhibitor of breast cancer. HDAC8-IN-12 triggers anti-tumor immunity by activating T cells, increasing the proportion of M1 macrophages and decreasing the proportion of M2 macrophages. HDAC8-IN-12 (50 mg/kg) exerts tumor suppressive effects in an orthotopic mouse model of breast cancer[1].
References[1] Natural Derivatives of Selective HDAC8 Inhibitors with Potent in Vivo Antitumor Efficacy against Breast Cancer
HDAC8-IN-12 Preparation Products And Raw materials
Tag:HDAC8-IN-12(3028095-13-5) Related Product Information
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