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| | MMs02943764 Basic information |
| Product Name: | MMs02943764 | | Synonyms: | MMs02943764;Acetamide, N-(2-bromo-4,6-difluorophenyl)-2-[[5-[[5-methyl-2-(1-methylethyl)phenoxy]methyl]-4-(2-propen-1-yl)-4H-1,2,4-triazol-3-yl]thio]- | | CAS: | 708287-29-0 | | MF: | | | MW: | 551.45 | | EINECS: | | | Product Categories: | | | Mol File: | 708287-29-0.mol |  |
| | MMs02943764 Chemical Properties |
| density | 1.410±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 10.013±0.70(predicted) | | form | Solid | | color | Off-white to light yellow |
| | MMs02943764 Usage And Synthesis |
| Uses | MMs02943764 is a 1,2,4-triazole derivative with anticancer activity. MMs02943764 has significant antiproliferative effects on multiple cancer cell lines. PAC, a structural analog of MMs02943764, has significant cytotoxicity against the leukemia cell line K562 (IC50=35.264 μM), reduces the degradation of p53 by inhibiting Mdm2 and Pirh2, and induces K562 cell cycle arrest[1]. | | References | [1] Niazi, et al. "Synthesis, characterization, and anti-cancer potential of novel p53-mediated Mdm2 and Pirh2 modulators: an integrated In silico and In vitro approach." Frontiers in Chemistry 12 (2024): 1366370. DOI:10.3389/fchem.2024.1366370 |
| | MMs02943764 Preparation Products And Raw materials |
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