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| | 6-Fluoro-1,2,3,4-tetrahydroquinoline Basic information |
| Product Name: | 6-Fluoro-1,2,3,4-tetrahydroquinoline | | Synonyms: | Quinoline, 6-fluoro-1,2,3,4-tetrahydro-;6-Fluoro-1,2,3,4-tetrahydroquinoline,97%;6-Fluoro-1,2,3,4-tetrahydroquinoline | | CAS: | 59611-52-8 | | MF: | C9H10FN | | MW: | 151.18 | | EINECS: | | | Product Categories: | | | Mol File: | 59611-52-8.mol |  |
| | 6-Fluoro-1,2,3,4-tetrahydroquinoline Chemical Properties |
| Melting point | 32-34℃ | | Boiling point | 248.0±29.0 °C(Predicted) | | density | 1.107±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 5.15±0.20(Predicted) | | Appearance | Off-white to light brown <32°C Solid,>34°C Liquid | | CAS DataBase Reference | 59611-52-8 |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | HS Code | 2933499090 |
| | 6-Fluoro-1,2,3,4-tetrahydroquinoline Usage And Synthesis |
| Uses | 6-Fluoro-1,2,3,4-tetrahydroquinoline is used as pharmaceutical intermediate. | | Synthesis | A THF solution of 6-fluoro-3,4-dihydroquinolin-2(1H)-one (6.0 g, 36.36 mmol) was slowly added to a THF (80 mL) suspension of LiAlH4 (2.76 g, 72.73 mmol) under stirring conditions. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction was quenched with saturated sodium chloride solution and ethyl acetate and filtered through diatomaceous earth. The filtrate was diluted with ethyl acetate and washed sequentially with water and saturated sodium chloride solution and the organic phase was dried with anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give 4.5 g (81% yield) of 6-fluoro-1,2,3,4-tetrahydroquinoline as a brown liquid.1H NMR (400 MHz, CDCl3): δ 6.65-6.78 (m, 2H), 6.37-6.40 (m, 1H), 3.26 (t, J=5.3 Hz, 2H), 2.73 (t, J=6.6 Hz, 2H), 1.88-1.94 (m, 2H). | | References | [1] Patent: WO2017/142883, 2017, A1. Location in patent: Paragraph 0183; 0186
[2] Patent: WO2014/78813, 2014, A1. Location in patent: Page/Page column 141 |
| | 6-Fluoro-1,2,3,4-tetrahydroquinoline Preparation Products And Raw materials |
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