| Company Name: |
Creative Enzymes |
| Tel: |
1-516-855-7709 |
| Email: |
info@creative-enzymes.com |
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| | CASPASE-1 Basic information |
| Product Name: | CASPASE-1 | | Synonyms: | ICE 1B HUMAN;IL-1BETA CONVERTING ENZYME;INTERLEUKIN-1BETA CONVERTING ENZYME;INTERLEUKIN-1B-CONVERTING ENZYME HUMAN;CASPASE-1 PROTEIN, RECOMBINANT HUMAN ACTIVE;CASPASE 1 HUMAN;CASPASE-1 HUMAN, RECOMBINANT, ACTIVE;CASPASE-1, HUMAN, RECOMBINANT, E COLI | | CAS: | 122191-40-6 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![CASPASE-1 Structure]() |
| | CASPASE-1 Chemical Properties |
| storage temp. | −70°C | | form | powder | | biological source | rabbit | | Specific Activity | ≥5000units/mg protein |
| WGK Germany | - | | Storage Class | 10 - Combustible liquids |
| | CASPASE-1 Usage And Synthesis |
| Uses | Caspase 1 human has been used in in vitro cleavage assay with Rab interacting lysosomal protein (RILP) and in the cleavage of caspases-3/7 in human monocyticcells (THP1). | | General Description | Caspase 1, also called interleukin (IL)-1-converting enzyme, is mapped to human 11q22.3. It belongs to the aspartate-specific cysteine proteases family and is primarily synthesized as procaspase-1 zymogen, which later become catalytically active post autoproteolysis. The enzymatically active caspase-1 comprises two p20/p10 heterodimer making it a tetramer. | | Biochem/physiol Actions | Caspase 1 catalyzes the conversion of pro-inflammatory cytokine, pro-interleukin (IL)-1β to its active form. It has broad substrate specificity and is an apoptosis regulator. Caspase-1 is indirectly implicated in the pathology of cryopyrin-associated periodic syndrome (CAPS). It is a multiple inflammasome-associated protein associated with multiple sclerosis (MS) lesions and is a prime target for inhibitor screening. |
| | CASPASE-1 Preparation Products And Raw materials |
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