| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
18210857532; 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:ZonisaMide-13C2-15N
CAS:1188265-58-8
Package:10Mg,1Mg
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| Company Name: |
Cato Research Chemicals Inc.
|
| Tel: |
020-81960175 |
| Email: |
min.he@cato-chem.com |
| Products Intro: |
Product Name:ZonisaMide-13C2-15N
CAS:1188265-58-8
Purity:95% Package:25Mg, 50Mg
|
| Company Name: |
Shanghai QianYan Bio-technology Co., Ltd
|
| Tel: |
02781293128 |
| Email: |
orders@biochemsafebuy.com |
| Products Intro: |
Product Name:Zonisamide-13C2-15N
CAS:1188265-58-8
Purity:>98% .NMR+LCMS Package:50Mg/100Mg/500Mg/1g/5g/10g/
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ZONISAMIDE-13C2-15N manufacturers
- Zonisamide-13C2,15N
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- $990.00 / 1mg
-
2025-08-21
- CAS:1188265-58-8
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | ZONISAMIDE-13C2-15N Basic information |
| | ZONISAMIDE-13C2-15N Chemical Properties |
| Melting point | 158 - 160°C | | storage temp. | Refrigerator | | solubility | DMSO (Sparingly), Methanol (Slightly) | | form | Solid | | color | Off-White to Light Yellow |
| | ZONISAMIDE-13C2-15N Usage And Synthesis |
| Description | Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent. It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml. In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium current. Zonisamide inhibits H. pylori recombinant carbonic anhydrase (CA) and the human CA isoforms I, II, and V with Ki values of 218, 56, 35, and 21 nM, respectively. In mice, it has anticonvulsant activity against maximal electroshock seizure (MES) and pentylenetetrazole-induced maximal, but not minimal, seizures (ED50s = 19.6, 9.3, and >500 mg/kg, respectively). Zonisamide (40 mg/kg, p.o.) prevents MPTP-induced decreases in the levels of dopamine , but not homovanillic acid (HVA; ) or dihydroxyphenyl acetic acid (DOPAC; ), and increases MPTP-induced decreases in the dopamine turnover rate in mouse striatum in a model of Parkinson''s disease. Formulations containing zonisamide have been used in the treatment of partial seizures in adults with epilepsy. | | Uses | Zonisamide-13C2-15N is the labeled analogue of Zonisamide (Z700000), a sulfonamide antiseizure agent; blocks repetitive firing of voltagesensitive sodium channels and reduces voltage-sensitive T-type calcium currents. Heterocyclic methanesulfonide with anticonvulsant properties. The compound is under investigation for potential therapeutic use as an antiepileptic drug. Anticonvulsant. | | References | [1] YOSHINOBU MASUDA Masanao S Masayuki Ishizaki. Zonisamide: Pharmacology and Clinical Efficacy in Epilepsy[J]. CNS drug reviews, 2006, 4 4: 341-360. DOI: 10.1111/j.1527-3458.1998.tb00075.x
[2] DAVID M ROCK Charles P T Robert L Macdonald. Blockade of sustained repetitive action potentials in cultured spinal cord neurons by zonisamide (AD 810, CI 912), a novel anticonvulsant[J]. Epilepsy Research, 1989, 3 2: Pages 138-143. DOI: 10.1016/0920-1211(89)90041-7
[3] SETSUO SUZUKI. Zonisamide blocks T-type calcium channel in cultured neurons of rat cerebral cortex[J]. Epilepsy Research, 1992, 12 1: Pages 21-27. DOI: 10.1016/0920-1211(92)90087-a
[4] ISAO NISHIMORI . Carbonic anhydrase inhibitors: Cloning and sulfonamide inhibition studies of a carboxyterminal truncated α-carbonic anhydrase from Helicobacter pylori[J]. Bioorganic & Medicinal Chemistry Letters, 2006, 16 8: Pages 2182-2188. DOI: 10.1016/j.bmcl.2006.01.044
[5] GIUSEPPINA DE SIMONE . Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies[J]. Bioorganic & Medicinal Chemistry Letters, 2005, 15 9: Pages 2315-2320. DOI: 10.1016/j.bmcl.2005.03.032
[6] HAYATO YABE . Zonisamide Increases Dopamine Turnover in the Striatum of Mice and Common Marmosets Treated With MPTP[J]. Journal of pharmacological sciences, 2009, 110 1: Pages 64-68. DOI: 10.1254/jphs.09019fp |
| | ZONISAMIDE-13C2-15N Preparation Products And Raw materials |
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