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| | p27Kip1 (C-Term) Rabbit Monoclonal Antibody (Clone RM302) Basic information |
| | p27Kip1 (C-Term) Rabbit Monoclonal Antibody (Clone RM302) Chemical Properties |
| | p27Kip1 (C-Term) Rabbit Monoclonal Antibody (Clone RM302) Usage And Synthesis |
| Description | p27Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase (CDK) inhibitor proteins encoded by CDKN1B in humans.1 It is an intrinsically disordered protein but does contain a structured N-terminal kinase inhibitor domain composed of a nuclear export signal, cyclin-binding subdomain (D1), CDK-binding subdomain (D2) that binds to CDKs to inhibit their catalytic activity, and linker subdomain that connects D1 and D2. p27Kip1 is ubiquitously expressed and shuttles from the nucleus to the cytoplasm in a cell cycle- or signaling-dependent manner. It has subcellular compartment-specific roles in cytoskeletal organization, autophagy, cytokinesis, and regulation of transcription, as well as regulation of cell proliferation, survival, differentiation, invasion, and motility.2 Germline mutations in CDKN1B have been found in tumor samples isolated from patients with multiple endocrine neoplasia type 1 and familial prostate cancer. Epithelial and stromal levels of p27Kip1 are decreased in women with endometriosis.3 Cayman’s p27Kip1 (C-Term) Rabbit Monoclonal Antibody (Clone RM302) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.WARNING This product is not for human or veterinary use. |
| | p27Kip1 (C-Term) Rabbit Monoclonal Antibody (Clone RM302) Preparation Products And Raw materials |
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