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| | CR2/CD21 (C-Term) Rabbit Monoclonal Antibody (Clone RM372) Basic information |
| | CR2/CD21 (C-Term) Rabbit Monoclonal Antibody (Clone RM372) Chemical Properties |
| | CR2/CD21 (C-Term) Rabbit Monoclonal Antibody (Clone RM372) Usage And Synthesis |
| Description | Complement receptor 2 (CR2), also known as CD21, is a type I transmembrane glycoprotein with a role in the complement system.1 It is composed of an extracellular domain that contains 15 or 16 short consensus repeats involved in stabilizing the triple-loop domain conformation, a transmembrane domain, and a short cytoplasmic domain containing one PKC and one tyrosine kinase phosphorylation site. CR2 is primarily expressed on mature B cells and follicular dendritic cells (FDCs) but is also expressed on the pharyngeal and cervical epithelium, thymocytes, and a subset of peripheral T cells.1,2 It forms a complex with CD19, TAPA-1, and Leu-19 on the surface of B cells, where it acts as a ligand-fixing subunit that binds surface-fixed cleavage fragments of complement protein C3 on antigen presenting cells to amplify antigen-induced B cell activation and antibody production.1 CR2 is also a receptor for Epstein Barr Virus. B cell levels of CR2 are decreased in patients with systemic lupus erythematosus (SLE).3 Cayman’s CR2/CD21 (C-Term) Rabbit Monoclonal Antibody (Clone RM372) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.WARNING This product is not for human or veterinary use. |
| | CR2/CD21 (C-Term) Rabbit Monoclonal Antibody (Clone RM372) Preparation Products And Raw materials |
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