|
|
| | Inostamycin A (sodium salt) Basic information |
| | Inostamycin A (sodium salt) Chemical Properties |
| solubility | Acetone: soluble
Chloroform: soluble
Methanol: soluble |
| | Inostamycin A (sodium salt) Usage And Synthesis |
| Description | Inostamycin A is a bacterial metabolite that has been found in Streptomyces and has anticancer activity.1 It is an inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase (IC50 = 0.02 µg/ml in A431 cell membranes) and is selective for CDP-diacylglycerol:inositol 3-phosphatidyltransferase over phospholipase C (PLC) and phosphatidylinositol kinase at 10 µg/ml.2 Inostamycin A decreases viability of YCU-T892, KCC-TC873, KB, HSC-4, and YCU-T891 oral squamous cell carcinoma (OSCC) cells in a concentration-dependent manner.3 It induces cell cycle arrest in the G1 phase in HSC-4 cells when used at a concentration of 250 ng/ml and induces apoptosis in Ms-1 small cell lung cancer cells at 300 ng/ml.3,4 Inostamycin A also reduces levels of matrix metalloproteinase-2 (MMP-2) and MMP-9 and inhibits EGF-induced migration of HSC-4 cells.5WARNING This product is not for human or veterinary use. | | References | [1] MASAYA IMOTO. Isolation and Structure Determination of Inostamycin, a Novel Inhibitor of Phosphatidylinositol Turnover[J]. Journal of Natural Products , 1990, 53 4: 825-829. DOI: 10.1021/np50070a008
[2] M IMOTO K U Y Taniguchi. Inhibition of CDP-DG: inositol transferase by inostamycin.[J]. Journal of biochemistry, 1992, 112 2: 299-302. DOI: 10.1093/oxfordjournals.jbchem.a123894
[3] YUH BABA. CYTOSTATIC EFFECT OF INOSTAMYCIN, AN INHIBITOR OF CYTIDINE 5′-DIPHOSPHATE 1,2-DIACYL-sn-GLYCEROL (CDP-DG): INOSITOL TRANSFERASE, ON ORAL SQUAMOUS CELL CARCINOMA CELL LINES[J]. Cell Biology International, 2013, 25 7: 613-620. DOI: 10.1006/cbir.2000.0706
[4] MASAYA IMOTO. Inhibition of Cyclin D1 Expression and Induction of Apoptosis by Inostamycin in Small Cell Lung Carcinoma Cells[J]. Cancer Science, 2005, 89 3: 315-322. DOI: 10.1111/j.1349-7006.1998.tb00564.x
[5] Y. BABA. Inostamycin, an inhibitor of cytidine 5′-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): Inositol transferase, suppresses invasion ability by reducing productions of matrix metalloproteinase-2 and -9 and cell motility in HSC-4 tongue carcinoma cell line[J]. Clinical & Experimental Metastasis, 2004, 65 1: 273-279. DOI: 10.1023/a:1006798900743 |
| | Inostamycin A (sodium salt) Preparation Products And Raw materials |
|