|
|
| | PANCREATIC POLYPEPTIDE (BOVINE) Basic information |
| Product Name: | PANCREATIC POLYPEPTIDE (BOVINE) | | Synonyms: | H-Ala-Pro-Leu-Glu-Pro-Glu-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Gln-Tyr-Ala-Ala-Glu-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Leu-Thr-Arg-Pro-Arg-Tyr-NH2;PANCREATIC POLYPEPTIDE (BOVINE);Pancreatic polypeptide (pig),6-L-glutamic acid-;Pancreatic Oligopeptide Powder | | CAS: | 179986-89-1 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | peptide | | Mol File: | Mol File | ![PANCREATIC POLYPEPTIDE (BOVINE) Structure]() |
| | PANCREATIC POLYPEPTIDE (BOVINE) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | Sequence | Ala-Pro-Leu-Glu-Pro-Glu-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Gln-Tyr-Ala-Ala-Glu-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Leu-Thr-Arg-Pro-Arg-Tyr-NH2 |
| | PANCREATIC POLYPEPTIDE (BOVINE) Usage And Synthesis |
| Uses | Pancreatic Polypeptide, bovine, a 36-amino acid, straight chain polypeptide derived primarily from the pancreas, inhibits secretin- and cholecystokinin-stimulated pancreatic secretion; Pancreatic Polypeptide, bovine acts as an agonist of NPY receptor, with high affinity at NPYR4. | | Biological Activity | Pancreatic Polypeptide, bovine is a linear polypeptide of 36 amino acids produced in the pancreas that inhibits pancreatic secretion induced by secretin and cholecystokinin. It is a neuropeptide (NPY) receptor agonist with high affinity for NPYR4. | | in vitro | Pancreatic Polypeptide, bovine is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic Polypeptide (1 μM) does not alter proliferation in BRIN BD11 or 1.1B4 beta-cells, but reverses the decreased cell viability in BRIN BD11 cells induced by streptozotocin. Pancreatic Polypeptide (0.1 nM-1 μM) shows no effect on insulin secretion from isolated mouse islets, and does not affect the membrane potential and (Ca 2+ ) i levels in BRIN BD11 cells at 1 μM. Pancreatic Polypeptide, bovine inhibits secretin- and cholecystokinin-stimulated pancreatic secretion. 125 I-Pancreatic Polypeptide, bovine shows no specific binding to pancreatic acini. | | in vivo | Pancreatic Polypeptide (25 nmol/kg bw, ip) reduces glucose-stimulated insulin concentrations but shows no effect on acute feeding behaviour in overnight fasted mice. Pancreatic Polypeptide, bovine (BPP; 40 μg/kg) inhibits CCK -33-induced pancreatic protein output during the entire bovine Pancreatic Polypeptide infusion period, but shows no effect on biliary protein output during CCK-33 or CCK-8 infusion. p> | | References | [1] Khan D, et al. Influence of neuropeptide Y and pancreatic polypeptide on islet function and beta-cell survival. Biochim Biophys Acta. 2017 Apr;1861(4):749-758. DOI:10.1016/j.bbagen.2017.01.005
[2] Louie DS, et al. Action of pancreatic polypeptide on rat pancreatic secretion: in vivo and in vitro. Am J Physiol. 1985 Oct;249(4 Pt 1):G489-95. DOI:10.1152/ajpgi.1985.249.4.G489 |
| | PANCREATIC POLYPEPTIDE (BOVINE) Preparation Products And Raw materials |
|