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| | 2-FLUORO-4-NITROBENZONITRILE Basic information |
| | 2-FLUORO-4-NITROBENZONITRILE Chemical Properties |
| Melting point | 0°C | | Boiling point | 0°C | | density | 1.41±0.1 g/cm3(Predicted) | | Fp | 0°C | | storage temp. | Sealed in dry,Room Temperature | | Appearance | Off-white to light yellow Solid | | CAS DataBase Reference | 34667-88-4(CAS DataBase Reference) |
| | 2-FLUORO-4-NITROBENZONITRILE Usage And Synthesis |
| Chemical Properties | Light yellow solid | | Synthesis | General procedure for the synthesis of 2-fluoro-4-nitrobenzonitrile from 2-fluoro-4-nitrobenzamide: A mixture of 2-fluoro-4-nitrobenzamide (0.83 g, 4.6 mmol) and phosphorus pentoxide/hexamethyldisiloxane in 1,2-dichloroethane (20 mL) was heated and refluxed for 4 hr at 100 °C under nitrogen atmosphere. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently filtered through a silicone plug, washed first with hexane (200 mL) and then with 5% methanol/chloroform mixture (400 mL). The methanol/chloroform washings were combined and concentrated under reduced pressure to give 2-fluoro-4-nitrobenzonitrile (0.71 g, 95% yield) as a beige solid.1H NMR (DMSO-d6) data were as follows: δ 8.46 (dd, J = 9.5, 2.0 Hz, 1H), 8.37-8.22 (m, 2H). | | References | [1] Journal of Heterocyclic Chemistry, 1997, vol. 34, # 4, p. 1163 - 1172
[2] Patent: US6344459, 2002, B1. Location in patent: Page column 70-71
[3] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 1325 - 1344
[4] Journal of Medicinal Chemistry, 2001, vol. 44, # 23, p. 3856 - 3871 |
| | 2-FLUORO-4-NITROBENZONITRILE Preparation Products And Raw materials |
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