- 6-Methoxy-1H-indanone
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- $10.00 / 1KG
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2026-03-20
- CAS:13623-25-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 5tons
- 6-Methoxy-1H-indanone
-
- $0.00 / 1kg
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2025-04-04
- CAS:13623-25-1
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1Ton
- 6-Methoxy-1-indanone
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- $0.00 / 1KG
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2022-01-27
- CAS:13623-25-1
- Min. Order: 1KG
- Purity: 98.5%
- Supply Ability: 100 tons
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| | 6-Methoxy-1H-indanone Basic information |
| | 6-Methoxy-1H-indanone Chemical Properties |
| Melting point | 105-109 °C (lit.) | | Boiling point | 228.88°C (rough estimate) | | density | 1.0281 (rough estimate) | | refractive index | 1.6000 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | form | Fine Crystalline Powder | | color | White to yellow | | BRN | 1238602 | | InChI | InChI=1S/C10H10O2/c1-12-8-4-2-7-3-5-10(11)9(7)6-8/h2,4,6H,3,5H2,1H3 | | InChIKey | UJGDLLGKMWVCPT-UHFFFAOYSA-N | | SMILES | C1(=O)C2=C(C=CC(OC)=C2)CC1 | | CAS DataBase Reference | 13623-25-1(CAS DataBase Reference) |
| | 6-Methoxy-1H-indanone Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powder | | Uses | Indanone derivative as a1-adrenoceptor antagonist. | | Uses | Indanone derivative as α1-adrenoceptor antagonist. | | Uses | 6-Methoxy-1-indanone was used in the synthesis of 5-methoxyninhydrin (2,2-dihydroxy-5-methoxy-1,3-indanedione). | | Synthesis Reference(s) | Journal of the American Chemical Society, 71, p. 1092, 1949 DOI: 10.1021/ja01171a092 | | Synthesis | General procedure for the synthesis of 6-methoxy-1-indanone from 3-(4-methoxyphenyl)propionic acid: trifluoromethanesulfonic acid (3 eq.) was slowly added to a solution of 3-(4-methoxyphenyl)propionic acid (0.5 mmol) dissolved in anhydrous CH2Cl2 (1.0 mL) in a 12 mL Q-tubepressure tube (provided by QLabtech). The reaction mixture was then warmed to room temperature. A PTFE septum was placed on top of the reaction tube and sealed with the appropriate cap and pressure adapter. The sealed reaction tube was heated in an oil bath at 80°C. The reaction process was monitored by thin layer chromatography (TLC) and gas chromatography-mass spectrometry (GC/MS) until the feedstock completely disappeared. After completion of the reaction, the mixture was poured into ice water and extracted three times with CH2Cl2. The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure. Finally, the target compound 6-methoxy-1-indanone was purified from the crude product by fast column chromatography. | | Purification Methods | Crystallise it from MeOH, then sublime it at high vacuum. [Beilstein 8 IV 894.] | | References | [1] Molecules, 2014, vol. 19, # 5, p. 5599 - 5610
[2] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 5, p. 470 - 475
[3] Organic and Biomolecular Chemistry, 2017, vol. 15, # 35, p. 7374 - 7379
[4] Synthetic Communications, 1991, vol. 21, # 21, p. 2231 - 2256
[5] Tetrahedron Letters, 2004, vol. 45, # 8, p. 1741 - 1745 |
| | 6-Methoxy-1H-indanone Preparation Products And Raw materials |
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