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Polyinosinic-polycytidylic acid sodium salt

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Company Name: HangZhou RunYan Pharma Technology Co.,LTD.
Tel: +8618882027439
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Products Intro: Product Name:Polyinosinic–polycytidylic acid sodium salt ; Poly (I: C); Poly (I:C) Na;
CAS:42424-50-0
Purity:90.0%Min. HPLC Package:1kg;0.00;USD|10kg;0.00;USD|50kg;0.00;USD
Company Name: WeiTai BioPharmaceutical Co.,Ltd(Hangzhou)
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Products Intro: Product Name:Polyi polycytidylic acid sodium salt(Poly I:C) (PIC)
CAS:42424-50-0
Purity:≥90% Package:1kg;|5kg;|10kg;
Company Name: Henan Tianfu Chemical Co.,Ltd.
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Products Intro: Product Name:Polyinosinic-polycytidylic acid sodium salt
CAS:42424-50-0
Purity:99% Package:25KG;5KG;1KG
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Products Intro: Product Name:Polyinosinic-polycytidylic acid sodium salt
CAS:42424-50-0
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Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:Polyinosinic-polycytidylic acid sodium
CAS:42424-50-0
Purity:98.00% Package:1mg;38USD|2mg;|5mg;88USD Remarks:REAGENT;FOR LABORATORY USE ONLY

Polyinosinic-polycytidylic acid sodium salt manufacturers
Polyinosinic-polycytidylic acid sodium salt Basic information
Product Name:Polyinosinic-polycytidylic acid sodium salt
Synonyms:POLYINOSINIC ACID + POLYCYTIDYLIC ACID, SODIUM SALT;Polymyocyte sodium salt;POLYINOSINIC ACID POLYCYTIDYLIC ACID, SODIUM SALT;POLYINOSINIC-POLYCYTIDYLIC ACID SODIUM SALT;POLY I POLY C, NA;POLY[I] POLY[C] SODIUM SALT;Oligochitosan-kanamycin-polyI-polyC sodium salt compound solution;Polyinosinic acid - polycytidylic acid sodium salt, double-stranded
CAS:42424-50-0
MF:C19H27N7O16P2
MW:671.41
EINECS:1308068-626-2
Product Categories:Biochemicals and Reagents;Biomaterials;Cell Culture;Materials Science;Nucleosides;Nucleotides;Oligonucleotide Polymers and Copolymers;Oligonucleotides;Other adjuvants;Synthetic Oligonucleotides and Related Reagents;Vaccine Adjuvants;Vaccine Production;Nucleoside Mono
Mol File:42424-50-0.mol
Polyinosinic-polycytidylic acid sodium salt Structure
Polyinosinic-polycytidylic acid sodium salt Chemical Properties
storage temp. −20°C
solubility H2O: soluble10mg/mL
form lyophilized powder
color White to off-white
biological sourcesynthetic (organic)
Water Solubility Water : 10 mg/mL (Need ultrasonic and warming)
InChIKeyACEVNMQDUCOKHT-WOQDZEJINA-N
SMILESO[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CC(N)=NC1=O)O.O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=NC2C(NC=NC1=2)=O)O |&1:1,2,3,11,22,23,24,32,r|
Safety Information
Safety Statements 22-24/25
WGK Germany 3
RTECS TR0175000
Storage Class11 - Combustible Solids
MSDS Information
ProviderLanguage
SigmaAldrich English
Polyinosinic-polycytidylic acid sodium salt Usage And Synthesis
DescriptionPolyinosinic-polycytidylic acid (Poly I:C) sodium salt (double-stranded) is a TLR3 (Toll-like receptor 3) agonist.
UsesTLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic-polycytidylic acid sodium salt is a double-stranded homopolymer used as a model RNA to study cell signaling at the level of TLR3. Poly I:C is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.
Biological ActivityPolyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis.
in vivoPolyinosinic-polycytidylic acid (Poly I:C) treatment inhibits tumor growth in NOD/SCID immunodeficient mice injected with 1205Lu cells. The level of human DNA is 50% lower in mice treated with Polyinosinic-polycytidylic acid[1].
IC 50TLR3
storageStore at -20°C
Polyinosinic-polycytidylic acid sodium salt Preparation Products And Raw materials
Tag:Polyinosinic-polycytidylic acid sodium salt(42424-50-0) Related Product Information
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