N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea

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N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: Shaoguan Qicheng Biotechnology Co., Ltd  
Tel: 18122215013
Email: 780229652@qq.com
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea manufacturers

  • AK963
  • AK963 pictures
  • $1520.00
  • 2026-07-27
  • CAS:445007-59-0
  • Purity:
  • Supply Ability: 10g
N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea Basic information
Product Name:N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea
Synonyms:N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea;AK963
CAS:445007-59-0
MF:C16H18N2O
MW:254.32692
EINECS:
Product Categories:
Mol File:445007-59-0.mol
N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea Structure
N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea Chemical Properties
Safety Information
MSDS Information
N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea Usage And Synthesis
DescriptionAK963, also known as 40708899, is a potent PAK1 (p21-activated kinase 1) inhibitor, which suppresses the proliferation of human gastric cancer cells significantly by downregulation of PAK1-NFκB-CyclinB1 pathway.
UsesAK963/40708899 is a potent PAK1 inhibitor. AK963/40708899 suppresses the proliferation of human gastric cancer cells by downregulation of PAK1-NF-κB-cyclinB1 pathway. AK963/40708899 induces cell cycle arrest at G2 phase and reduces the migration and invasion. AK963/40708899 inhibits the formation of filopodia and promots cell adhesion which in turn inhibits invasive potential of gastric cells by negatively regulating PAK1-LIMKl-cofilin and PAK1-ERK-FAK pathways[1].
IC 50PAK1
References[1] Ying Zhou, et al. Targeting PAK1 with the Small Molecule Drug AK963/40708899 Suppresses Gastric Cancer Cell Proliferation and Invasion by Downregulation of PAK1 Activity and PAK1-Related Signaling Pathways. Anat Rec (Hoboken). 2019 Sep;302(9):1571-1579. DOI:10.1002/ar.24095
N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea Preparation Products And Raw materials
Tag:N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea(445007-59-0) Related Product Information
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