- 2-Chloro-3-hydroxypyridine
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- $15.00 / 1KG
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2021-07-13
- CAS:6636-78-8
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | 2-Chloro-3-hydroxypyridine Basic information |
| | 2-Chloro-3-hydroxypyridine Chemical Properties |
| Melting point | 170-172 °C (lit.) | | Boiling point | 316.2±22.0 °C(Predicted) | | density | 1.2309 (rough estimate) | | refractive index | 1.4510 (estimate) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 4.32±0.10(Predicted) | | form | Powder | | color | Light beige | | BRN | 2216 | | InChI | InChI=1S/C5H4ClNO/c6-5-4(8)2-1-3-7-5/h1-3,8H | | InChIKey | RSOPTYAZDFSMTN-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC=CC=C1O | | CAS DataBase Reference | 6636-78-8(CAS DataBase Reference) | | NIST Chemistry Reference | 2-Chloro-3-pyridinol(6636-78-8) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-20/21/22 | | Safety Statements | 26-37/39-24/25-36 | | WGK Germany | 3 | | RTECS | UU7707000 | | HazardClass | IRRITANT | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-Chloro-3-hydroxypyridine Usage And Synthesis |
| Chemical Properties | light beige powder | | Uses | 2-Chloro-3-hydroxypyridine has been used in the preparation of 3-hydroxypyridine-2( 1 H)-selone. It has also been used in the synthesis of all four possible benzo[4,5]furopyridine tricyclic heterocycles: benzo[4,5]furo[2,3-b]pyridine, benzo[4,5]furo[2,3-c]pyridine, benzo[4,5]furo[3,2-c]pyridine, and benzo[4,5]furo[3,2-b]pyridine. the synthesis involves α and γ-activation of chloropyridines, as well as palladium-mediated reactions. | | Synthesis | GENERAL METHOD: To a solution of 2-chloro-3-pyridyl trifluoromethanesulfonate (0.3 mmol) in anhydrous toluene (5 mL) was added Cs2CO3 (3 equiv). The reaction suspension was heated at 80 °C (oil bath temperature) with stirring for 15 hours. Upon completion of the reaction, the crude reaction mixture was quenched with ethyl acetate (~5 mL) and saturated aqueous ammonium chloride solution (~10 mL). The aqueous layer was separated and extracted with ethyl acetate (2 x 10 mL). The organic layers were combined, dried with anhydrous MgSO4 and concentrated under reduced pressure to give the crude product 2-chloro-3-hydroxypyridine. Finally, the product was purified by fast column chromatography on silica gel. | | References | [1] Tetrahedron Letters, 2013, vol. 54, # 51, p. 7078 - 7079 |
| | 2-Chloro-3-hydroxypyridine Preparation Products And Raw materials |
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