|
|
| | Cyclopiazonic acid Basic information |
| Product Name: | Cyclopiazonic acid | | Synonyms: | ALPHA CYCLOPIAZONIC ACID;CYCLOPIAZONIC ACID, PENICILLIUM CYCLOPIUM;PENICILLIUM CYCLOPIUM;(6AR,11AS,11BR)-REL-10-ACETYL-2,6,6A,7,11A,11B-HEXAHYDRO-7,7-DIMETHYL-9H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-9-ONE;(6AA, 10Z, 11AB, 11BA)-6A,7,11A,11B-TETRAHYDRO-10-(1-HYDROXYETHYLIDENE)-7,7- DIMETHYL-6H-PYRROLO [1',2':2,3]ISOINDOLO [4,5,6-CD]INDOLE-9,11 (2H,10H)-DIONE;6H-Pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indole-9,11(2H,7H)-dione, 6a,10,11a,11b-tetrahydro-10-(1-hydroxyethylidene)-7,7-dimethyl-, (6aR,10Z,11aS,11bR)-;Cyclopiazonic acid in acetonitrile;CPA | | CAS: | 83136-88-3 | | MF: | C20H20N2O3 | | MW: | 336.38 | | EINECS: | 2005854 | | Product Categories: | | | Mol File: | 83136-88-3.mol |  |
| | Cyclopiazonic acid Chemical Properties |
| Melting point | 245-246 °C | | storage temp. | −20°C | | solubility | DMSO: soluble | | form | powder | | color | white to off-white |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 36/37/39-45 | | RIDADR | UN 2811 6.1/PG 2 | | WGK Germany | 3 | | RTECS | UY8587000 | | Toxicity | Cyclopiazonic acid is a natural contaminant of
cheese, corn, and peanuts. Due to the lack of analytical methods
for quantifying cyclopiazonic acid, the amount present in
the food supply and the potential health risks are uncertain.
Cyclopiazonic acid distributes widely in mammalian tissues,
especially skeletal muscle, and produces equally diverse cytotoxicity.
This toxicant shares many pharmacological properties
with antipsychotic drugs including catalepsy, hypothermia,
hypokinesia, ptosis, tremor, gait disturbance, sedation without
loss of righting reflex, atypical convulsion, and increased barbiturate
sleeping time. The mode of action of cyclopiazonic
acid involves its role as an inhibitor of Ca-ATPase. |
| | Cyclopiazonic acid Usage And Synthesis |
| Uses | Cyclopiazonic Acid is an inhibitor of endoplasmic reticulum Ca2+-ATPase. | | Definition | ChEBI: Alpha-cyclopiazonic acid is a member of alpha-cyclopiazonic acids. It is a conjugate acid of an alpha-cyclopiazonate. It is a tautomer of a (6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one. |
| | Cyclopiazonic acid Preparation Products And Raw materials |
|