- 5-Pyrimidinemethanol
-
- $1.10 / 1g
-
2025-11-18
- CAS:25193-95-7
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons
- 5-Pyrimidine methanol
-
- $15.00 / 1KG
-
2021-07-13
- CAS:25193-95-7
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 5-Pyrimidine methanol
-
- $15.00 / 1KG
-
2021-07-09
- CAS:25193-95-7
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
|
| | 5-Pyrimidinemethanol Basic information |
| | 5-Pyrimidinemethanol Chemical Properties |
| Melting point | 51-52 °C | | Boiling point | 250.8±15.0 °C(Predicted) | | density | 1.227±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 13.43±0.10(Predicted) | | form | solid | | color | Yellow | | CAS DataBase Reference | 25193-95-7(CAS DataBase Reference) |
| | 5-Pyrimidinemethanol Usage And Synthesis |
| Uses | 5-Pyrimidinemethanol is a reagent used in the synthesis of melanin-concentrating hormone receptor 1 antagonists.Also used in the preparation of annulated 5-aryl-substituted pyridines. | | Synthesis | Step 3. Synthesis of 5-pyrimidinemethanol. 5-Pyrimidinecarboxaldehyde (2 g, 18.50 mmol, 1.00 eq.) and sodium borohydride (2 g) were dissolved in methanol (100 mL) and the reaction was stirred for 30 min at 0-10 °C. Upon completion of the reaction, the solvent was removed by vacuum concentration and the resulting residue was purified by silica gel column chromatography with dichloromethane/methanol (50:1, v/v) as eluent to give 1.2 g (59% yield) of the target compound 5-pyrimidine methanol as a light yellow solid. Mass spectrometry result: m/z = 111.0 [M + H]+. | | References | [1] Patent: WO2013/130935, 2013, A1. Location in patent: Paragraph 0218
[2] Patent: WO2013/19621, 2013, A1. Location in patent: Page/Page column 41
[3] Journal of Organic Chemistry, 2000, vol. 65, # 26, p. 9261 - 9264
[4] Patent: WO2009/45381, 2009, A1. Location in patent: Page/Page column 29-30
[5] Patent: WO2009/45386, 2009, A1. Location in patent: Page/Page column 32-33 |
| | 5-Pyrimidinemethanol Preparation Products And Raw materials |
|