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| | 3-Amino-4-bromo-6-chloropyridazine Basic information | | Appearance |
| Product Name: | 3-Amino-4-bromo-6-chloropyridazine | | Synonyms: | 3-Amino-4-bromo-6-chloropyridazine;4-Bromo-6-chloro-3-pyridazinamine;3-AMino-4-broMo-6-chlorop...;4-bromo-6-chloro-3-pyridazineamine;3-PyridazinaMine,4-broMo-6-chloro-;3-Amino-4-bromo-6-chL;3-Amino-4-bromo-6-chloropyridazine ISO 9001：2015 REACH;3-Amino-4-bromo-6-chloropyridazine 98% | | CAS: | 446273-59-2 | | MF: | C4H3BrClN3 | | MW: | 208.44 | | EINECS: | | | Product Categories: | Risdiplam | | Mol File: | 446273-59-2.mol |  |
| | 3-Amino-4-bromo-6-chloropyridazine Chemical Properties |
| Boiling point | 385.4±37.0 °C(Predicted) | | density | 1.960 | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 1.93±0.10(Predicted) | | form | powder | | color | Light brown to brown | | InChI | InChI=1S/C4H3BrClN3/c5-2-1-3(6)8-9-4(2)7/h1H,(H2,7,9) | | InChIKey | FGOWNGCSUSKHQI-UHFFFAOYSA-N | | SMILES | C1(N)=NN=C(Cl)C=C1Br |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN2811 | | HS Code | 2933998090 |
| | 3-Amino-4-bromo-6-chloropyridazine Usage And Synthesis |
| Appearance | Pale-yellow to yellow-brown Solid | | Uses | 4-Bromo-6-chloropyridazin-3-amine is a compound involved in the preparation of novel potent imidazo[1,2-b]pyridazine PDE10a inhibitors. | | Synthesis | Example I (1) Bromine (9.71 g, 3.15 mL, 60.75 mmol) was slowly added dropwise to a mixed solution containing 3-amino-6-chloropyridazine (7.87 g, 60.75 mmol), methanol (115 mL) and sodium bicarbonate (10.22 g, 121.67 mmol). The reaction mixture was stirred at room temperature for 16 hours and then filtered. Water (500 mL) was added to the filtrate and subsequently extracted with ethyl acetate (3 × 500 mL). The organic layers were combined and concentrated under reduced pressure. The resulting residue was purified by fast chromatography using 1:1 hexane/ethyl acetate as eluent, resulting in 5.40 g of 3-amino-4-bromo-6-chloropyridazine in 43% yield. | | References | [1] Patent: WO2014/9305, 2014, A1. Location in patent: Page/Page column 29
[2] Patent: US2015/203498, 2015, A1. Location in patent: Paragraph 0155; 0156; 0157
[3] Patent: WO2009/100375, 2009, A1. Location in patent: Page/Page column 44-45
[4] Patent: WO2010/42699, 2010, A1. Location in patent: Page/Page column 114-115
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 23, p. 10414 - 10423 |
| | 3-Amino-4-bromo-6-chloropyridazine Preparation Products And Raw materials |
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