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| | N,N'-DIACETYLGLYCINE ANHYDRIDE Basic information |
| Product Name: | N,N'-DIACETYLGLYCINE ANHYDRIDE | | Synonyms: | 1,4-DIACETYL-PIPERAZINE-2,5-DIONE;1,4-DIACETYLTETRAHYDRO-2,5-PYRAZINEDIONE;1,4-DIACETYL-2,5-DIKETOPIPERAZINE;1,4-DIACETYL-2,5-DIOXOPIPERAZINE;1,4-DIACETYL-2,5-PIPERAZINEDIONE;N,N′-Diacetyl-2,5-dioxopiperazine;2,5-Piperazinedione, 1,4-diacetyl-;N,N'-Diacetylglycine Anhydride | | CAS: | 3027-05-2 | | MF: | C8H10N2O4 | | MW: | 198.18 | | EINECS: | | | Product Categories: | | | Mol File: | 3027-05-2.mol |  |
| | N,N'-DIACETYLGLYCINE ANHYDRIDE Chemical Properties |
| Melting point | 99-100°C | | Boiling point | 424.4±38.0 °C(Predicted) | | density | 1.375±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | form | powder to crystal | | pka | -1.74±0.20(Predicted) | | color | White to Light yellow to Light orange | | BRN | 188115 | | InChI | InChI=1S/C8H10N2O4/c1-5(11)9-3-8(14)10(6(2)12)4-7(9)13/h3-4H2,1-2H3 | | InChIKey | CBBKKVPJPRZOCM-UHFFFAOYSA-N | | SMILES | N1(C(C)=O)CC(=O)N(C(C)=O)CC1=O |
| Hazard Codes | Xn | | Risk Statements | 36/37/38-43-36/38-22 | | Safety Statements | 26-36/37/39-36/37 | | WGK Germany | 3 | | HS Code | 2933.59.9500 | | HazardClass | IRRITANT | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1 |
| | N,N'-DIACETYLGLYCINE ANHYDRIDE Usage And Synthesis |
| Description | ?N,N'-diacetylglycine anhydride, also known as diacetylated glycylglycine, can be obtained by acylation of glycylglycine with acetic anhydride. N,N'-diacetylglycine anhydride can be used to prepare DL-neopentylglycine derivatives. | | Preparation | After the mixed reaction of glycylglycine and acetic anhydride, ethyl acetate and petroleum ether are added in sequence to obtain the intermediate N,N'-diacetylglycine anhydride. | | Application | N,N'-diacetylglycine anhydride can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical and pharmaceutical synthesis process. | | Synthesis | GENERAL METHOD: 2,5-Piperazinedione (500 mg, 2.5 mmol) was mixed with ethanoic anhydride (20 mL) and reacted at 150°C overnight. Upon completion of the reaction, the excess acetic anhydride was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography to afford 1,4-diacetylpiperazine-2,5-dione. | | References | [1] Journal of Organic Chemistry, 2015, vol. 80, # 5, p. 2554 - 2561
[2] Synthesis (Germany), 2014, vol. 46, # 5, p. 621 - 628
[3] European Journal of Medicinal Chemistry, 2014, vol. 83, p. 236 - 244
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993, # 11, p. 1217 - 1224
[5] Tetrahedron, 2012, vol. 68, # 36, p. 7374 - 7379 |
| | N,N'-DIACETYLGLYCINE ANHYDRIDE Preparation Products And Raw materials |
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