- p-Acetoacetanisidide
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- $0.00 / 1kg
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2025-09-04
- CAS:5437-98-9
- Min. Order: 1kg
- Purity: 98.0%
- Supply Ability: 1kg/month
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| | 4'-Methoxyacetoacetanilide Basic information |
| | 4'-Methoxyacetoacetanilide Chemical Properties |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 26-36/37/39 | | RTECS | AK4598010 | | HS Code | 2924297099 |
| | 4'-Methoxyacetoacetanilide Usage And Synthesis |
| Chemical Properties | WHITE TO VERY SLIGHTLY YELLOW POWDER | | Uses | N-(4-Methoxyphenyl)-3-oxobutanamide is an intermediate in the synthesis of Tafenoquine-d3 Succinate is the labelled analog of Tatenoquine (T004760), a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the prevention and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 11, p. 803, 1946 DOI: 10.1021/jo01176a024 | | Synthesis | GENERAL STEPS: In a 100 mL round-bottomed flask, ethyl acetoacetate (0.03 mol) was added to a stirring solution of p-aminoanisole (0.01 mol) dissolved in 10 mL of PEG-300. The reaction mixture was refluxed at 120 °C for 1.5-2 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was cooled to room temperature and subsequently extracted with cold ether (3 x 10 mL). The organic phases were combined and purified by column chromatography (eluent: hexane solution of 10-25% ethyl acetate) to afford the target product N-(4-methoxyphenyl)-3-oxobutylamide (3a-p). The structure of the final product was confirmed by methods reported in the literature. | | References | [1] Synthetic Communications, 2000, vol. 30, # 20, p. 3709 - 3718
[2] Heterocycles, 2008, vol. 75, # 11, p. 2681 - 2701
[3] European Journal of Organic Chemistry, 2015, vol. 2015, # 14, p. 3171 - 3177
[4] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 13, p. 1639 - 1641
[5] Journal of Chemical Sciences, 2014, vol. 126, # 1, p. 187 - 195 |
| | 4'-Methoxyacetoacetanilide Preparation Products And Raw materials |
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