- Isocurcumenol
-
- $0.00 / 5mg
-
2023-02-24
- CAS:24063-71-6
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
- Isourecumenol
-
- $9.80 / 1KG
-
2020-02-11
- CAS:24063-71-6
- Min. Order: 1g
- Purity: ＞98%
- Supply Ability: 20 tons
|
| | Isocurcumenol Basic information |
| Product Name: | Isocurcumenol | | Synonyms: | (+)-Isocurcumenol;(3S,8aβ)-1,2,3,4,5,7,8,8a-Octahydro-3α-methyl-8-methylene-5-(1-methylethylidene)-6H-3aα,6α-epoxyazulen-6-ol;Isocurcumenol;isourecumenol;6H-3a,6-Epoxyazulen-6-ol, octahydro-3-methyl-8-methylene-5-(1-methylethylidene)-, (3S,3aS,6R,8aS)-;(3S,3aS,6R,8aS)-3-Methyl-8-methylene-5-(propan-2-ylidene)octahydro-6H-3a,6-epoxyazulen-6-ol;Isocurcumenol, 10 mM in DMSO | | CAS: | 24063-71-6 | | MF: | C15H22O2 | | MW: | 234.33 | | EINECS: | | | Product Categories: | | | Mol File: | 24063-71-6.mol |  |
| | Isocurcumenol Chemical Properties |
| Melting point | 142-143℃ | | Boiling point | 351.0±42.0 °C(Predicted) | | density | 1.09±0.1 g/cm3(Predicted) | | storage temp. | -20°C, protect from light | | solubility | DMF: 1 mg/ml,DMSO: 1 mg/ml,Ethanol: slightly soluble | | pka | 12.70±0.40(Predicted) | | form | Powder | | color | White to off-white | | LogP | 2.837 (est) |
| | Isocurcumenol Usage And Synthesis |
| Uses | Isocurcumenol, an estrogen receptor alpha (ERα) inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC50 values of 99.1μg/mL and 178.2 μg/mL in DLA and KB cells, respectively[1][2]. | | Hazard | A poison by ingestion. | | target | 5α-Reductase | | References | [1] Lakshmi S, et al. Antitumour Effects of Isocurcumenol Isolated from Curcuma zedoaria Rhizomes on Human and Murine Cancer Cells. Int J Med Chem. 2011;2011:253962. DOI:10.1155/2011/253962
[2] Resmi Mustarichiei, et al. In silico study of curcumol, curcumenol, isocurcumenol, and β-sitosterol as potential inhibitors of estrogen receptor alpha of breast cancer. Basic Medical Research. 2014 |
| | Isocurcumenol Preparation Products And Raw materials |
|