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| | CARBONIC ACID TERT-BUTYL 2,4,5-TRICHLOROPHENYL ESTER Basic information |
| Product Name: | CARBONIC ACID TERT-BUTYL 2,4,5-TRICHLOROPHENYL ESTER | | Synonyms: | 1-(TERT-BUTOXYCARBONYLOXY)-2,4,5-TRICHLOROBENZENE;Carbonic acid, 1,1-dimethylethyl 2,4,5-trichlorophenyl ester;carbonicacid,1,1-dimethylethyl2,4,5-trichlorophenylester;t-Butyl 2,4,5-trichlorophenyl carbonate;TIMTEC-BB SBB005395;TERT-BUTYL 2,4,5-TRICHLOROPHENYL CARBONATE;CARBONIC ACID TERT-BUTYL 2,4,5-TRICHLOROPHENYL ESTER;Einecs 241-039-5 | | CAS: | 16965-08-5 | | MF: | C11H11Cl3O3 | | MW: | 297.56 | | EINECS: | 241-039-5 | | Product Categories: | Biochemistry;Condensation & Active Esterification;Peptide Synthesis;Protection & Derivatization Reagents (for Synthesis);Protective Reagents (Peptide Synthesis);Synthetic Organic Chemistry;Carbonates;Carbonyl Compounds;Organic Building Blocks;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks | | Mol File: | 16965-08-5.mol |  |
| | CARBONIC ACID TERT-BUTYL 2,4,5-TRICHLOROPHENYL ESTER Chemical Properties |
| WGK Germany | 3 | | TSCA | TSCA listed |
| | CARBONIC ACID TERT-BUTYL 2,4,5-TRICHLOROPHENYL ESTER Usage And Synthesis |
| Uses | Used as reagent for the Boc protection of amino groups;
preparation of active esters for peptide synthesis | | Synthesis | tert-Butyl 2,4,5-Trichlorophenyl Carbonate is prepared by the reaction between 2,4,5-trichlorophenol and Phosgene in toluene at -10 °C in the presence of dimethylaniline gives 2,4,5-trichlorophenyl chloroformate. Treatment with t-butanol and quinoline in CH2Cl2 then affords t-butyl 2,4,5-trichlorophenyl carbonate. | | Purification Methods | Crystallise the carbonate from a mixture of MeOH (90mL) and water (6mL) using charcoal [Broadbent et al. J Chem Soc (C) 2632 1967, Fieser & Fieser Reagents for Organic Synthesis 2 55 1969]. |
| | CARBONIC ACID TERT-BUTYL 2,4,5-TRICHLOROPHENYL ESTER Preparation Products And Raw materials |
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