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| | Ethyl 6-chloronicotinate Basic information |
| | Ethyl 6-chloronicotinate Chemical Properties |
| Melting point | 26-30 °C(lit.) | | Boiling point | 98 °C | | density | 1.245±0.06 g/cm3(Predicted) | | refractive index | 1.522 | | Fp | >230 °F | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | -1.95±0.10(Predicted) | | form | Solid | | color | Colourless to Off-White Oil | | BRN | 4742175 | | InChI | 1S/C8H8ClNO2/c1-2-12-8(11)6-3-4-7(9)10-5-6/h3-5H,2H2,1H3 | | InChIKey | ILDJJTQWIZLGPO-UHFFFAOYSA-N | | SMILES | CCOC(=O)c1ccc(Cl)nc1 | | CAS DataBase Reference | 49608-01-7(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2 |
| | Ethyl 6-chloronicotinate Usage And Synthesis |
| Chemical Properties | White to light yellow solid or colorless to yellow liquid | | Uses | Ethyl 6-chloronicotinate is a nicotinic acid derivative used in the preparation of potent H3 receptor antagonists. | | Uses | Ethyl 6-chloropyridine-3-carboxylate (Ethyl 6-chloronicotinate) may be used in the preparation of ethyl 5-{[5-(1H-benzimidazol-2-yl)pyridin-2-yl]ethynyl}pyridine-2-carboxylate by reacting with 2-[6-(ethynyl)pyridin-3-yl]-1H-benzimidazole under microwave irradiation. | | General Description | Ethyl 6-chloropyridine-3-carboxylate (Ethyl-6-chloronicotinate, E-6-ClN) undergoes direct amidation on reacting with benzylamine in the presence lanthanum trifluoromethanesulfonate La(OTf)3. The structural and physicochemical properties of E-6-ClN have been investigated based on its spectroscopic data, time-dependent density functional theory and density of state diagrams. |
| | Ethyl 6-chloronicotinate Preparation Products And Raw materials |
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