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| | 2-Chloro-6-(trifluoromethyl)pyridine Basic information |
| | 2-Chloro-6-(trifluoromethyl)pyridine Chemical Properties |
| Melting point | 33 °C | | Boiling point | 60-62°C 8mm | | density | 1.416±0.06 g/cm3(Predicted) | | Fp | 78°C | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | Water Solubility | Insoluble in water | | form | powder to lump | | pka | -4.30±0.10(Predicted) | | color | White to Almost white | | FreezingPoint | 32.0 to 34.0 ℃ | | BRN | 4308910 | | InChI | InChI=1S/C6H3ClF3N/c7-5-3-1-2-4(11-5)6(8,9)10/h1-3H | | InChIKey | ADVQMCQMDHBTHJ-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC(C(F)(F)F)=CC=C1 | | CAS DataBase Reference | 39890-95-4(CAS DataBase Reference) |
| Hazard Codes | T;Xn,Xi,Xn,T | | Risk Statements | 25-20/21/22-36/37/38-36 | | Safety Statements | 26-36/37/39-45-36/37-9-36 | | RIDADR | 2811 | | WGK Germany | 3 | | Hazard Note | Irritant | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29333990 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 2 Oral
Eye Irrit. 2 |
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ALFA
| English |
| | 2-Chloro-6-(trifluoromethyl)pyridine Usage And Synthesis |
| Chemical Properties | Colorless to off-white liquid (or White to off-white crystal) | | Uses |
2-Chloro-6-(trifluoromethyl)pyridine can be used in the synthesis of medicine, pesticide or biocidal product.
| | Chemical Reactivity | 2-Chloro-6-(trifluoromethyl)pyridine is stable under recommended storage conditions, it reacts with strong oxidizing agents, strong acids, strong bases. | | Synthesis | General procedure for the synthesis of 2-chloro-6-trichloromethylpyridine from 2-chloro-6-trichloromethylpyridine: 2-chloro-6-trichloromethylpyridine (700 g, 3.03 mol, feed rate 1.24 g/min) and anhydrous hydrogen fluoride (936 g, 46.8 mol, feed rate 1.66 g/min) were added successively to a tubular reactor fitted with a preactivated chromium oxide-alumina catalyst (210 g) in a tubular reactor at a reaction temperature of 330 °C. The reaction products were cooled with ice water and collected. The reaction products were collected after cooling with ice water and extracted with dichloromethane. The extract was washed with 10% potassium hydroxide solution, and the organic layer was separated and concentrated to give 490.0 g of crude 2-chloro-6-trifluoromethylpyridine, which was analyzed by GC for 95.03% purity and 89% reaction yield. The crude product was purified by fractionation to obtain 2-chloro-6-trifluoromethylpyridine with 98.0% purity and 80.0% yield. | | References | [1] Patent: WO2016/178248, 2016, A1. Location in patent: Page/Page column 5 |
| | 2-Chloro-6-(trifluoromethyl)pyridine Preparation Products And Raw materials |
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