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| | (2-AMINO-4-PYRIDYL)BORONIC ACID Basic information |
| Product Name: | (2-AMINO-4-PYRIDYL)BORONIC ACID | | Synonyms: | (2-AMINO-4-PYRIDYL)BORONIC ACID;2-aminopyridin-4-ylboronic acid;2-Aminopyridine-4-boronic acid;2-aMino-4-pyridinyl boronic acid;(2-Aminopyridin-4-yl);Boronic acid, B-(2-amino-4-pyridinyl)-;(2-Aminopyridin-4-yl)boronicaci;(2-AMINO-4-PYRIDYL)BORONIC ACID ISO 9001：2015 REACH | | CAS: | 903513-62-2 | | MF: | C5H7BN2O2 | | MW: | 137.93 | | EINECS: | 1533716-785-6 | | Product Categories: | 6 | | Mol File: | 903513-62-2.mol |  |
| | (2-AMINO-4-PYRIDYL)BORONIC ACID Chemical Properties |
| Boiling point | 411.7±55.0 °C(Predicted) | | density | 1.33±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C | | pka | 5.74±0.10(Predicted) | | Appearance | Off-white to gray Solid |
| | (2-AMINO-4-PYRIDYL)BORONIC ACID Usage And Synthesis |
| Synthesis | General procedure for the synthesis of (2-aminopyridin-4-yl)boronic acid from 2-amino-4-chloropyridine: 2-amino-4-chloropyridine (3 g, 23.34 mmol), bis(pinacolato)diboron (17.78 g, 70.1 mmol), 2-dicyclohexylphosphino-2',6'-dimethoxybiphenyl (0.38 g, 0.93 mmol), tris( dibenzylideneacetone) dipalladium(0) (0.21 g, 0.23 mmol) and potassium acetate (3.89 g, 39.67 mmol) were mixed in 1,4-dioxane (78 mL) under nitrogen atmosphere. The reaction mixture was stirred at 100 °C for 3 hours. Upon completion of the reaction, the hot reaction mixture was filtered through diatomaceous earth and washed with ethyl acetate (EtOAc). The organic layer was concentrated under vacuum and the residue was precipitated with diisopropyl ether (DIPE) to afford the intermediate compound 1-24 ((2-aminopyridin-4-yl)boronic acid) as a white solid (5.84 g, quantitative yield), which could be used in the next reaction without further purification. | | References | [1] Patent: WO2014/195311, 2014, A1. Location in patent: Page/Page column 88
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 7, p. 1879 - 1882 |
| | (2-AMINO-4-PYRIDYL)BORONIC ACID Preparation Products And Raw materials |
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