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| | TERT-BUTYL 4-(HYDROXYIMINO)PIPERIDINE-1-CARBOXYLATE Basic information |
| Product Name: | TERT-BUTYL 4-(HYDROXYIMINO)PIPERIDINE-1-CARBOXYLATE | | Synonyms: | TERT-BUTYL 4-(HYDROXYIMINO)PIPERIDINE-1-CARBOXYLATE;1-Piperidinecarboxylic acid, 4-(hydroxyiMino)-, 1,1-diMethylethyl ester;1-Boc-4-(hydroxyimino)piperidine;tert-Butyl 4-(hydroxyimino);N-BOC-4-(hydroxyimino)piperidine;4-Hydroxyimino-piperidine-1-carboxylic acid tert-butyl ester;tert-butyl 4-(hydroxyimino)piperidin-1-carboxylate | | CAS: | 150008-24-5 | | MF: | C10H18N2O3 | | MW: | 214.26 | | EINECS: | | | Product Categories: | | | Mol File: | 150008-24-5.mol |  |
| | TERT-BUTYL 4-(HYDROXYIMINO)PIPERIDINE-1-CARBOXYLATE Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | Appearance | Off-white to yellow Solid |
| | TERT-BUTYL 4-(HYDROXYIMINO)PIPERIDINE-1-CARBOXYLATE Usage And Synthesis |
| Uses | tert-Butyl 4-(hydroxyimino)piperidine-1-carboxylate is a useful intermediate for organic synthesis. | | Synthesis | The general procedure for the synthesis of 4-oxime-1-Boc-piperidine using N-Boc-4-piperidone as starting material is as follows: 1 equiv. of N-Boc-4-piperidone, 1.6 equiv. of hydroxylamine hydrochloride, and 2.0 equiv. of sodium acetate were dissolved in an aqueous methanol solution, mixed homogeneously, and then heated to reflux the reaction. Upon completion of the reaction, the target product 4-oxime-1-Boc-piperidine was obtained in quantitative yield. The synthetic method was applicable for the preparation of all oxime substrates in this study. | | References | [1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 9, p. 2942 - 2945
[2] Tetrahedron Letters, 2010, vol. 51, # 24, p. 3216 - 3217
[3] Tetrahedron Letters, 2011, vol. 52, # 10, p. 1074 - 1077
[4] Patent: EP1477490, 2004, A1. Location in patent: Page 109
[5] Patent: WO2008/150447, 2008, A1. Location in patent: Page/Page column 206 |
| | TERT-BUTYL 4-(HYDROXYIMINO)PIPERIDINE-1-CARBOXYLATE Preparation Products And Raw materials |
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